摘要
目的 :观察冠状动脉口旁注射硫酸镁预处理对内皮素 - 1(ET- 1)所致心律失常的作用。方法 :在雄性 SD大鼠冠状动脉口近旁注射内皮素 - 1引起室性早搏、室性心动过速、心室纤维性颤动、房室传导阻滞等严重心律失常 ,观察冠状动脉口近旁注射不同剂量的硫酸镁预处理对 ET- 1所致心律失常发生率的影响。结果 :硫酸镁 (45 m g/kg)组较 ET- 1对照组心律失常发生率和大鼠死亡率明显降低 (P<0 .0 5 ,P<0 .0 1) ;硫酸镁 (90 m g/kg)组 ,严重心律失常未发生 ,动物无死亡。结论 :硫酸镁有拮抗 ET-
In order to study the mechanism of exogenous endothelin to induce arrhythmias,magnesium sulphate was injected close to coronary ostia before ET 1 administration and its effects on ET 1 induced severe arrhythmias were observed,which included premature ventricular contraction,ventricular tachycardia,ventricular fibrillation and atrio ventricular block. The results showed that magnesium sulphate dose dependently reduced ET 1 induced arrhythmias. It indicated that magnesium could intervene the pathway of ET 1 to induce arrhythmias.
出处
《心脏杂志》
CAS
2000年第2期81-83,共3页
Chinese Heart Journal
基金
全军"九五"医学科研基金! ( No.96M0 72 )
