摘要
目的 :探讨血管内皮细胞生长因子和血管生成与大肠癌发展的关系。方法 :应用免疫组化 S- P法 ,检测6 2例人大肠癌组织 VEGF蛋白表达和微血管密度 (MVD) ,分析 VEGF和 MVD、及其与大肠癌组织学分型、Dukes分期、癌肿浸润转移的关系。结果 :VEGF表达强度和 MVD与大肠癌的 Dukes分期 (P<0 .0 5 )、淋巴结转移 (P<0 .0 5 )及远处转移 (P<0 .0 1)密切相关 ,而与组织学分型无关 (P>0 .0 5 ) ,MVD与 VEGF表达两者呈正相关 (r=0 .89)。结论 :VEGF与大肠癌的血管生成密切相关 ,对大肠癌的生长和浸润转移有促进作用 ,VEGF和 MVD可作为反映大肠癌生物学行为的指标之一。
Objective:To investigate the relationship between vascular endothelial growth factor (VEGF),angiogenesis and the development of colorectal carcinoma.Methods:VEGF protein expression and microvessel density(MVD) in 62 colorectal cancers were examined by means of immunohistochemical staining.MVD and VEGF expression and their relationships were analyzed together with histologic types,Dukes period and metastasis of colorectal carcinoma.Results:MVD and VEGF expression positively correlated with Dukes period ( P <0 05),lymph node metastasis( P <0 05) and distant metastasis( P <0 01),but no significant correlation with the histologic type( P >0 05).There was a positive correlation between MVD and VEGF expression ( r =0 89).Conclusions:VEGF is highly related to angiogenesis of colorectal carcinoma and promotes growth,invasion and metastasis of co lorectal carcinoma.VEGF expression or MVD may be one of the predictors for the biological behavior of colorectal carcinoma.
出处
《中国慢性病预防与控制》
CAS
2000年第4期171-173,共3页
Chinese Journal of Prevention and Control of Chronic Diseases
关键词
大肠部
血管内皮生长因子
血管生成
转移
Colorectal carcinoma
Vascular endothelial growth factor
Angiogenesis
Metastasis
