摘要
目的 :研究肺癌患者体液免疫指标的变化及其与CEA的关系。方法 :用自动生化分析仪和放免法定量测定 80例肺癌患者的血清球蛋白、IgG、IgA、IgM及补体 3(C3)、补体 4 (C4 )的量 ,设肺炎和正常人两组为对照组 ,运用SPSS软件进行统计。结果 :肺癌组的球蛋白、IgG、IgA比肺炎和正常人明显升高(P <0 0 5) ,C3则比正常人降低 (P <0 0 5) ,IgM、C4 两组无差异 (P >0 0 5) ,CEA阳性和CEA阴性肺癌患者免疫球蛋白、补体均无差异 (P >0 0 5) ,肺癌患者的血清CEA与IgA浓度呈显著正相关 (P <0 0 1)。结论 :肺癌患者的体液免疫功能增强 ;
Objective:To study the changes of globulin,IgG,IgA,IgM,C 3 and C 4 in the patients with lung cancer,and find out the correlation between these indexes and CEA.Methods:The serum globulin,IgG,IgA,IgM,C 3 and C 4 were determined by an autobiochemical analyzer,and CEA were determined by radioimmunity method in 80 patients,while patients with pneumonia and healthy people as controls.The method of statistical analysis was SPSS.Results:The serum globulin,IgG and IgA in the patients with lung cancer were significantly higher than those in the two controls (P<005),while C 3 was significantly lower than the healthy people (P<005).No significant differences of these serum indexes were observed between two groups with CEA positive and negative in the patients with lung cancer.A statistically significant positive correlation was found between CEA and IgA(P<0.01).Conclusions:Humoral immunity of patients with lung cancer is increased;there was a significant positive correlation between CEA and IgA,and CEA maybe was one of factors who induced higher secretion of IgA.
出处
《肿瘤防治杂志》
2000年第4期367-369,共3页
China Journal of Cancer Prevention and Treatment
