摘要
目的：观察牛肺泡表面活性物质（珂立苏）治疗新生儿呼吸窘迫综合征（RDS）的临床疗效。方法：研究对象为2011年3月-2012年12月期间明确诊断为新生儿RDS的182例早产儿，胎龄≤35周，除常规应用机械通气和综合治疗外，应用肺泡表面活性物质（PS）治疗，其中应用珂立苏治疗者94例（观察组），猪肺泡表面活性物质（固尔苏）88例（对照组），对比两组机械通气相关指标、疗效指标、治疗后合并症发生率和转归，进行统计学分析。结果：研究发现用药后两组患儿临床症状均有所改善，血气分析指标好转，观察组起效时间慢于对照组，差异具有统计学意义（P〈0．05）。对照组应用固尔苏治疗后1h平均气道压（MAP）和吸人氧浓度（FiO2）可下调，氧合指数（P／F）值有所改善，与观察组比较差异具有统计学意义（P〈0．05），但氧分压（PaO2）、二氧化碳分压（PaCO2）比较差异无统计学意义（P〉0．05）。上述指标在12h、24h、48h均有所改善，但差异无统计学意义（P〉0．05）。两组患者机械通气时间、用氧时间、住院时间比较差异无统计学意义（P〉0．05），治疗费用比较观察组低于对照组，差异具有统计学意义（P〈0．05）。两组各种并发症比较差异无统计学意义（P〉0．05）。两组患儿好转率、死亡率差异无统计学意义（P〉0．05）。结论：珂立苏与固尔苏治疗新生儿RDS时疗效相当，固尔苏起效较珂立苏快，但珂立苏能在一定程度上减少住院费用。
Objective： To observe the clinical curative effect of cattle pulmonary surfactant （Calsurf） in treatment of neonatal re- spiratory distress syndrome （NRDS） . Methods： One hundred and eighty -two premature infants diagnosed as NRDS definitely from March 2011 to December 2012 were selected as study objects, the fetal age was 35 weeks or less than 35 weeks; all the premature infants were trea- ted with routine therapy （ mechanical ventilation and comprehensive treatment）, while 94 premature infants in observation group were treated with Calsurf, 88 premature infants in control group were treated with swine pulmonary surfactant （Curosurf） ; the related indexes of mechani- cal ventilation, the indexes of curative effect, the incidence rates of complications after treatment, and prognosis in the two groups were com- pared and analyzed statistically. Results： After treatment, the clinical symptoms and the indexes of blood gas analysis in the two groups were improved, the onset time in observation group was statistically significantly slower than that in control group （P 〈 0.05） . In control group, the mean airway pressure （MAP） and fraction of inspired oxygen （FiO2） at one hour after treatment decreased, the oxygenation index in- creased, compared with observation group, there were statistically significant difference （P 〈 0. 05）, but there was no statistically significant difference in oxygen partial pressure （ PaO2 ） and partial pressure of carbon dioxide （ PaCO~ ） between the two groups （P 〉 0. 05 ） . The in- dexes above - mentioned were improved at 12, 24, and 48 hours after treatment, but there was no statistically significant difference between the two groups （P 〉 0. 05） . There was no statistically significant difference in duration time of mechanical ventilation, time of oxygen thera- py, and hospitalization time between the two groups （P 〉 0. 05）, the treatment cost in observation group was statistically significantly lower than that in control group （P 〈 0. 05） . There was no statistically significant difference in the incidence rates of complications, improvement rate, and mortality between the two groups （P 〉 0.05） . Conclusion ： Both Calsurf and have similar effects on treatment of NRDS, while the onset time of Curosurf is faster than that of Calsurf, but Calsurf can reduce hospitalization expenses to a certain extent.
出处
《中国妇幼保健》
CAS
北大核心
2013年第25期4152-4155,共4页
Maternal and Child Health Care of China
