摘要
[目的]系统评价根治性放疗与根治性手术治疗膀胱癌临床效果。[方法]应用END-NOTE软件全面检索Pubmed(1973～2013年)数据库,对符合纳入标准的临床对照试验,采用RevMan4.3软件进行Meta分析。对于无对照临床研究资料,采用同质合并分析。[结果]共纳入6个临床对照试验,共1264例患者,Meta分析结果显示,根治性放疗与根治性手术切除治疗膀胱癌患者的5年生存率无统计学差异(P=0.36),合并比值比(OR)为1.10(95%CI:0.86～1.40)。18篇无对照临床研究共纳入根治性放疗治疗膀胱癌患者1749例,多数文献采用全膀胱放疗40～60Gy,联合以顺铂为基础的化疗方案,完全反应率达到65%以上,平均5年总生存率在50%以上,最低为37%,最高可达82%。[结论]根治性放疗不会降低膀胱癌患者生存率,且能维持正常膀胱功能,提高了患者生存质量。
[Purpose] To investigate the response of radical cystectomy or radical radiotherapy for patients with bladder cancer muscle invaded. [Methods] The trails（randomized controlled trails and uncontrolled clinical trials） in Pubmed（1973～2013）were searched by ENDNOTE software. Meta-analysis was performed on the results of homogenous studies by RevMan 4.3.[Results] Six controlled clinical trials（1264 patients） were enrolled. The Meta-analysis results showed no statistical difference of 5-year survival between radical radiotherapy treatment group and radical surgery group （OR=1.10,95%CI： 0.86～1.40,P=0.36）. Eighteen clinical uncontrolled trials （1749 patients underwent by radical radiotherapy） were enrolled,most of the patients underwent radical radiotherapy（40～60Gy） and combined with cisplatin based chemotherapy. The complete response rate achieved 65%,the average 5-year survival was more than 50%（ 37%～82%）. [Conclusions] Radical radiotherapy will not reduce the survival rate in patients with bladder cancer muscle invaded. And it can maintain the normal bladder function and improve quality of life.
出处
《中国肿瘤》
CAS
2013年第8期671-675,共5页
China Cancer
