期刊文献+

急性肺栓塞患者血清心肌酶、心肌肌钙蛋白Ⅰ的检测及其临床意义 被引量:4

Detection of Serum Myocardial Enzymes and Cardiac Troponin Ⅰ and Its Significance in Patients with Acute Pulmonary Embolism
下载PDF
导出
摘要 目的探讨血清心肌酶及心肌肌钙蛋白Ⅰ(cTnⅠ)检测在急性肺栓塞(pulmonary embolism,PE)中的应用。方法使用全自动生化分析仪、采用免疫发光法检测61例急性PE患者[大面积、次大面积急性PE(大面积、次大面积组)39例,非大面积急性PE(非大面积组)22例]cTnⅠ水平,使用全自动生化分析仪检测2组患者血清心肌酶[天门冬氨酸转氨酶(AST)、磷酸肌酸激酶(CK)、磷酸肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、α-羟丁酸脱氢酶(α-HBDH)]水平。结果大面积、次大面积组血清cTnⅠ、AST、LDH、CK、CK-MB、α-HBDH水平均显著高于非大面积组(均P<0.05)。结论急性PE常伴有心肌细胞损伤,应常规行血清心肌酶及cTnⅠ测定,血清心肌酶及cTnⅠ的测定有助于危险分层。 Objective To investigate the application of the detection of serum myocardial enzymes and cardiac troponin I (cTn I ) in acute pulmonary embolism(PE).Methods The serum levels of cTn I , aspartic transaminase(AST),creatine phosphokinase (CK),creatine phosphokinase MB isoenzyme (CK- MB),lactate dehydrogenase(LDH),α-hydroxybutyrate dehydrogenase (α-HBDH)were determined using automatic biochemical analyzer in 39 patients with acute massive or submassive PE (massive/ submassive group) and 22 patients with acute non-massive PE (non-massive group). Results The levels of cTn I ,AST, LDH, CK, CK-MB and α-HBDH in massive/submassive group were significantly higher than those in non-massive group (all P〈0.05). Conclusion Acute PE is often accompanied by myocardial cell injury. The determination of serum myocardial enzymes and cTn I may contribute to risk stratification and should be performed routinely in patients with acute PE.
出处 《实用临床医学(江西)》 CAS 2013年第6期29-30,34,共3页 Practical Clinical Medicine
关键词 肺栓塞 急性 心肌酶 心肌肌钙蛋白Ⅰ 临床意义 pulmonary embolism, acute myocardial enzymes cardiac troponin I clinical significance
  • 相关文献

参考文献7

  • 1Ohigashi H, Haraguchi G, Yoshikawa S,et al.Comparison of biomarkers for predicting disease severity and long- term respiratory prognosis in patients with acute pulm- onary embolism[J].Int Heart J,2010,51 (6):416-420.
  • 2Wicki J ,Perneger T V ,Junod A F ,et al.Assessing clinical probability of pulmonary embolism in the emergency ward: a simple score[J].Arch Intern Med,2001,161 (1): 92-97.
  • 3Jimenez D, Uresandi F, Otero R, et al.Troponin -base d risk stratification of patients with acute nonmassive pul- monary embolism:systematic review and metaanalysis [J]. Chest, 2009,136 (4) : 974-982.
  • 4肺血栓栓塞症的诊断与治疗指南(草案)[J].中华结核和呼吸杂志,2001,24(5):259-264. 被引量:1838
  • 5Torbicki A,Perrier A,Konstantinides S,et al.Guidelines on the diagnosis and management of acute pulmonary embolism:the task force for the diagnosis and manage- ment of acute pulmonary embolism of the european soci- ety of cardiology (ESC) [ J ].Eur Heart J, 2008,29 ( 18 ) : 2276-2315.
  • 6Prastam M,Paolillo S,Savarese G,et al.N-terminal pro- b-type natriuretic peptide and left atrial function in pati- ents with congestive heart failure and severely reduced ejection fraction[J ].Eur J Echocardiogr,2011,12 (7) :506- 513.
  • 7Ng P L,Kwok C H,Tsui S H,et al.Raised tmponin I in Chinese patients with acute pulmonary embolism suggests complicated clinical course and may predict intensive care unit admission [J ]. Singapore Med J, 2013,54 (2) : 86-89.

共引文献1837

同被引文献31

引证文献4

二级引证文献9

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部