摘要
目的探讨复发鼻咽癌发生Ⅰ区淋巴结转移的危险因素。方法对51例复发鼻咽癌患者,应用免疫组化法检测原发及复发鼻咽活检组织VEGF及P53、MDM2、P21WAF1、P21ras蛋白的表达,采用卡方分析法检验Ⅰ区转移的危险因素。结果在51例中发生Ⅰ区转移9例;当鼻咽癌侵及鼻腔同时伴有VEGF高表达时,Ⅰ区转移率(37.5%)明显高于其它患者(8.6%),P=0.020。结论鼻咽癌侵及鼻腔与VEGF表达能在一定程度上反映复发患者Ⅰ区转移的风险。
Object： nasopharyngeal The objective of this study was to find the risk factors for level I metastasis in recurrent carcinoma （NPC）. Methods fifty one recurrent NPC were selected for the research. The expression level of VEGF, P53, MDM2, P21WAF1, P21ras protein were examined in IHC method. The χ2 test was used to verify the risk factors. Result There are 9 cases of level I metastasis in all 51 cases. When the nasal cavity involvement accompanied with high expression of VEGF, the level I metastasis rate （37.5%） was significant higher others （ 8.6% ）, P = 0.020. Conclusion The nasal cavity involvement and expression level of VEGF maybe a valuable index reflex the risk of level I metastasis.
出处
《现代诊断与治疗》
CAS
2013年第8期1694-1695,共2页
Modern Diagnosis and Treatment
关键词
复发鼻咽癌
Ⅰ区淋巴结转移
VEGF
Recurrent nasopharyngeal carcinoma
Level I metastasis
VEGF
