期刊文献+

原发性高血压患者血浆纤维蛋白原水平与颈动脉粥样硬化斑块的关系 被引量:2

Relationship between level of plasma fibrinogen and carotid atherosclerotic plaques in patients with essential hypertension
下载PDF
导出
摘要 目的探讨原发性高血压(EH)患者颈动脉粥样硬化斑块及性质与血浆纤维蛋白原(FIB)的关系。方法纳入EH患者404例,根据是否合并颈动脉硬化斑块分为斑块组(n=235)和无斑块组(n=169),对两组受试者血浆纤维蛋白原(FIB)水平及斑块性质(分为软斑块、硬斑块、混合斑块)进行比较,并运用多因素回归分析对颈动脉粥样硬化斑块性质与血压、血脂、血糖、FIB关系进行研究。结果①斑块组FIB及低密度脂蛋白胆固醇(LDL-C)明显高于无斑块组[FIB:(3.92±2.82)g/L vs.(3.23±1.62)g/L,P=0.032;LDL-C:(3.23±0.91)mmol/Lvs.(2.95±0.82)mmol/L,P=0.047],而HDL-C低于无斑块组[(1.17±0.31)mmol/Lvs.(1.25±0.35)mmol/L,P=0.021);②软斑块组患者血浆FIB水平高于混合斑块[(4.18±2.89)g/Lvs.(3.84±2.16)g/L,P<0.05]和硬斑块[(4.18±2.89)g/L vs.(3.69±2.21)g/L,P<0.05],混合斑块与硬斑块患者之间无明显差异;③高FIB血症者颈动脉斑块检出率及软斑块比例均显著高于FIB正常者(74.7%vs.42.9%,P<0.05;32.5%vs.8.1%,P<0.05);④多元回归分析发现血FIB水平、LDL-C与颈动脉斑块成正相关,HDL-C与颈动脉斑块成负相关。结论高血压患者血浆FIB水平与颈动脉斑块,尤其是软斑块密切相关。 Objective To investigate the relationship between level of plasma fibrinogen (FIB) and carotid atherosclerotic plaques in patients with essential hypertension (EH). Methods EH patients (n=454) were chosen and divided, according to whether or not they had complicated carotid atherosclerotic plaques, into plaque group (n=235) and non-plaque group (n=169). The level of plasma FIB and the properties of plaques (soft plaques, hard plaques and compound plaques) were compared between two groups. The properties of plaques and levels of blood pressure, blood fat, blood sugar and FIB were analyzed by using multi-factor regression. Results ①The levels of FIB and LDL-C were significantly higher in plaque group than that in non-plaque group [FIB:(3.92±2.82) g/L vs. (3.23±1.62) g/L, P=0.032;LDL-C:(3.23±0.91) mmol/L vs. (2.95±0.82) mmol/L, P=0.047], and level of HDL-C was lower in plaque group than that in non-plaque group [(1.17±0.31) mmol/L vs. (1.25±0.35) mmol/L, P=0.021)].②The level of plasma FIB was significantly higher in soft plaque group than that in compound plaque group [(4.18 ±2.89) g/L vs. (3.84±2.16) g/L, P〈0.05] and hard plaque group [(4.18±2.89) g/L vs. (3.69±2.21) g/L, P〈0.05]. There was no significant difference between compound plaque group and hard plaque group. ③The detection rate of carotid atherosclerotic plaques and proportion of soft plaques were significantly higher in the patients with hyperfibrinogenemia than those with normal FIB level (74.7%vs. 42.9%, P〈0.05;32.5%vs. 8.1%, P〈0.05). ④The multi-factor regression showed that carotid atherosclerotic plaques were positively correlated to the levels of FIB and LDL-C and negatively to the level of HDL-C. Conclusion The level of plasma FIB is closely related to carotid atherosclerotic plaques, especially to soft plaques in hypertensive patients.
出处 《中国循证心血管医学杂志》 2013年第4期366-368,共3页 Chinese Journal of Evidence-Based Cardiovascular Medicine
关键词 原发性高血压 颈动脉斑块 血浆纤维蛋白原 Essential hypertension Carotid atherosclerotic plaques Plasma fibrinogen
  • 相关文献

参考文献9

  • 1Wang L,Kong L,Wu F,et al. Preventing chronic diseases in China[J]. Lancet,2005,366(9499):1821-4.
  • 2Mathiesen EB,Bonaa KH,Joakimsen O. Echolucent plaques are associated with high risk of ischemic cerebrovascular events in carotid stenosis: the Tromso Study[J]. Circulation,2001,103(17):2171-5.
  • 3Touboul PJ,Labreuche J,Vicaut E,et al. GENIC Investigators. Carotid intima-media thickness,plaques,and Framingham risk score as independent determinants of stroke risk[J]. Stroke,2005,36(8): 1741-5.
  • 4Perk J,De Backer G,Gohlke H,et al. European guideline on cardiovascular disease prevention in clinical practice[J]. European Heart Journal,2012,33(13): 1635-701.
  • 5中国高血压防治指南2010[J].中华心血管病杂志,2011,39(7):579-616. 被引量:4549
  • 6Peeters W,Hellings WE,de Kleijn DP. Carotid atherosclerotic plaques stabilize after stroke insights into the natural process of atherosclerotic plaque stabilization[J]. Arterioscler Thromb Vasc Biol,2009,29(1):128-33.
  • 7李爽,石磊,孙艳萍,佟安铭,陈彤,谭晓红,吴丹.老年患者急性脑梗死与颈动脉粥样硬化的关系探讨[J].神经疾病与精神卫生,2006,6(3):192-193. 被引量:3
  • 8Halle M,Berg A,Keul J,et al. Association between serum fibrinogen concentration and HDL and LDL subfraction phenotypes in heathy men[J]. Arterioscler Thromb Vase Biol, 1996,16( 1 ): 144.
  • 9Fibrinogen studies collaboration. Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: An individual participant meta-analysis[J]. JAMA,2005,294(14):1799-$09.

二级参考文献7

  • 1Espeland MA,Hoen H,Byington R,et al.Spatial distribution of carotid intimal-media thickness as measured by B-ultrasonography[J].Stroke,1994,25:1 812-1 819.
  • 2Nagai Y,Kitagawa K,Saksguchi M,et al.Significence of earlier carotid atherosclerosis for stroke subtypes[J].Stroke,2001,32(32):1 780-1 785.
  • 3Bots ML,Hoes Aw,Hofman A,et al.Cross-sectionally assessed carotid intima-media thickness relates to long-term risk of stroke,cornary heart disease and death as estimated by available risk functions[J].J Intern Med,1999,245:269-276.
  • 4Iamuzzi A,Wilcosky T,Mercuri M,et al.Ultrasonographic correlates of carotid atherosclerosis in transient ischemic attack and stroke[J].Stroke,1995,26:614-619.
  • 5Yo Shiomis,Kazuo K,Yoji N,et al.Carotid atherosclerosis as a risk factor for complex aortic lesions in patients with ischemic cerebrovascular disease[J].Circ J,2003,67:597-600.
  • 6Cho YP,Kwon TW,Kim GE.Sonographic appearance of a freefloating atheromatous plaque in a patient with acute stroke[J].J Clin Ultrasound,2002,30:317-321.
  • 7叶有强,黄雪玲,王深明,胡作军,陈国锐.双功能彩色多普勒对颈内动脉狭窄的诊断[J].中国超声医学杂志,2002,18(6):444-446. 被引量:42

共引文献4550

同被引文献8

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部