摘要
目的观察蛇毒血凝酶在行根治性膀胱全切除术术中和术后的止血效果。方法适合根治性膀胱全切术的膀胱癌患者30例,随机分成蛇毒血凝酶组和对照组,每组患者各15例。蛇毒血凝酶组术前15 min、术中分别静脉滴注蛇毒血凝酶1 U,用浸泡蛇毒血凝酶生理盐水溶液的纱布压迫盆腔创面止血,术后静脉滴注蛇毒血凝酶1 U/d,连续3 d;对照组用0.9%氯化钠注射液。分别记录术中出血量、术后3 d的腹腔及盆腔总引流量,同时观察蛇毒血凝酶对凝血指标的影响。结果蛇毒血凝酶组与对照组术中出血量分别为(358±105)g与(672±182)g,术后总引流量分别为(257±138)g和(356±166)g,以上指标蛇毒血凝酶组均少于对照组(P<0.05)。两组术前和术后凝血指标无明显差异(P>0.05)。结论蛇毒血凝酶在膀胱癌适合根治性膀胱全切术中具有显著的止血效果,安全性能良好,能明显缩短手术时间.减少术中、术后出血和围手术期的输血。
Objective To observe the hemostatic effect of Hemocoagulase in intraoperative and postoperative of the radical cystectomy .Methods 30 cases with bladder cancer who were suitable for radical total cystectomy were randomly divided into the Hemoeoagulase group and the control group, 15 cases in each group. 15 min before the operation and intraoperative, the Hemocoagulase group was respectively injected hemocoagulase 1 U. Etamine soaked with hemocoagulase physiological saline solution was used to oppress the pelvic wound for hemostasis. Hemoeoagulase was injected for 3 days after operation, 1 U / d. At the same time, 0.9% sodium chloride was used in control group.Blood loss, abdominal and pelvic total lead flow for 3 days after operation were recorded, while observing the coagulation indicators. Results： Blood loss of the Hemocoagulase group and the control group respectively was （358 ＋ 105） g, （672 ＋ 182） g, total postoperative drainage volume was （257 ＋ 138） g . （356 ：e 166） g. The above datas of the hemocoagulase group less than that of the control group （P〈0.05）. Coagulation indicators have no signifieant difference （P〉0.05） before and after operation. Conclusion Hemocoagulase has significant hemostatic effect and sate in cases with bladder cancer who were suitable for radical total cystectomy, it can significantly shorten the operation time, reduce intraoperative, postoperative bleeding and pefioperative blood transfusion.
出处
《当代医学》
2013年第26期7-8,共2页
Contemporary Medicine
