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新疆喀什伽师县维吾尔族妇女HPV的分布研究 被引量:7

Research on distribution of HPV subtypes among Uyghur women in Payziwat County Kaxkar
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摘要 目的探讨新疆喀什地区伽师县克孜勒博依乡维吾尔族妇女人群HPV(Human papilloma virus,人乳头瘤病毒)感染情况及HPV感染与不同程度宫颈病变的关系,为制定新疆农村妇女宫颈癌防治对策和措施提供科学依据。方法于2011年6月15日-7月15日在伽师县克孜勒博依乡选择30~60岁的1 300例维吾尔族妇女为主要研究对象。所有研究对象接受问卷调查、妇检、HPV-DNA检测(HC-Ⅱ)、液基细胞学检查,对于HPV-DNA检测(HC-Ⅱ)与液基细胞学检查任意一项阳性者行阴道镜下宫颈活组织检查。结果 (1)喀什地区伽师县克孜勒博依乡妇女HPV总阳性率为10.31%。宫颈液基细胞异常率为2.77%。(2)不同宫颈病变脱落细胞中HPV DNA负荷量中位数最高为宫颈癌,最低为慢性宫颈炎,慢性宫颈炎组与CIN组及宫颈癌组比较,差异有统计学意义(P<0.05);CIN各组和宫颈癌组之间比较差异无统计学意义(P>0.05)。(3)HPV感染组中,细胞学阳性率分别为:ASCUS 42.11%、ASC-H 50%、LSIL 66.7%、HSIL 66.7%、浸润癌100%,与HPV非感染组阳性率比较差异有统计学意义(P<0.05);随着宫颈病变程度的加重,HPV阳性率也逐渐升高,且在各种宫颈细胞学病例中HPV感染的阳性率差异有统计学意义(P<0.05)。结论 HPV感染率与宫颈病变严重程度有关;宫颈细胞学异常与HPV感染有关;高病毒负荷量可能比患宫颈癌及宫颈上皮内瘤变的风险更大,但是不能用来预测宫颈病变的严重程度。 Objective By investigating the infection of human papillomavirus (HPV ) and distribution of HPV subtypes in population ,and the relation between HPV infections with squamous intraepithelial lesion in the Kizilbuy village in Kashgar Xinjiang ,provides a scientific basis for the development of cervical canc-er prevention strategies and measures .Methods A population based cervical cancer screening was done from June15 to July 15 ,2011 ,among 1 ,300 women in Kizilbuy township of Payzawat ,Kashgar ,Xinjiang ranging in age from 30 to 60 .And all of the objectives were carried through questionnaire performing , HPV-DNA testing ,liquid-based Cytology the patient who had positive for the HPV-DNA testing and liq-uid-based cytology was put up colposcopic biopsy .Results (1) 134(10 .31% ) women in all were HPV positive ,diagnosis ≥ASCUS by liquid-based cytology was 2 .77% (36/1 ,300) .(2) In different cervical le-sions ,the highest median load shedding of HPV is cervical cancer ,and the lowest is chronic cervicitis . When Chronic cervicitis group compared with the CIN group ,the difference was statistically significant (P〈0 .05);Comparison between the CIN group and cervical cancer group was not statistically significant (P〉0 .05) .(3) In HPV infected group ,positive ratio of cytologic test was 42 .11% in ASCUS ,50% in ASC-H ,66 .7% in LSIL ,66 .7% in HSIL and 100% in Invasive carcinoma .There was a statistically sig-nificance in this group .Conclusion The positive rate of HPV related to the severity of cervical disease , the positive rate of cytology related to HPV positivity ;High viral load is likely to suffer a greater risk of cervical cancer and cervical intraepithelial neoplasia ,but can not be used to predict the severity of cervical lesions .
出处 《新疆医科大学学报》 CAS 2013年第9期1357-1361,1356,共5页 Journal of Xinjiang Medical University
基金 国家自然科学基金(30860325)
关键词 人乳头瘤病毒 负荷量 新疆农村 维吾尔族 human papiloma virus virus load Xinjiang rural area Uyghur
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  • 1黄霞,张红,蒋登华.兵团第四师妇女子宫颈癌筛查结果分析[J].农垦医学,2014,36(3):253-256. 被引量:1
  • 2陶萍萍,卞美璐,李敏,刘军.HPV多重感染与宫颈病变关系探讨[J].中国妇产科临床杂志,2006,7(2):94-96. 被引量:112
  • 3姜淑清,邓小虹,冉齐钢.妇女病普查工作体会[J].中国妇幼保健,2006,21(19):2647-2648. 被引量:7
  • 4Forouzanfar MH,Foreman KJ,Delossantos AM,Lozano R,Lopez AD,Murray C J,Naghavi M.Breast and cervical cancer in 187 countries between 1980and 2010:a systematic analysis[J] .Lancet 2011;378(9801):1461-1484.
  • 5Romaguera D,Vergnaud AC,Peeters PH,Van Gils CH,Chan DS,Ferrari P,Romieu I,Jenab M,Slimani N,Clavel-Chapelon F,Norat T.Is concordance with World Cancer Research Fund/American Institute for Cancer Research guidelines for cancer prevention related to subsequent risk of cancer Results from the EPIC study[J] .Am J Clin Nutr 2012 ; 96(1):150-163.
  • 6Van der MeideWF,Snellenberg S,Meijer CJ,Baalbergen A,Helmerhorst TJ,van der Sluis WB,Snijders PJ,Steenbergen RD.Promoter methylation analysis of WNT/beta-catenin signaling pathway regulators to detect adenocarcinoma or its precursor lesion of the cervix[J] .Gynecol Oncol 2011 ; 123(1):116-122.
  • 7Noordhuis MG Fehrmann RS,Wisman GB,Nijhuis ER,Van Zanden J J,Moerland PD,Ver Loren Van Themaat E,Voiders HH,Kok M,ten Hoor KA et al:Involvement of the TGF·beta and beta-catenin pathways in pelvic lymph node metastasis in early-stage cervical cancer[J] .Clin CancerRes,2011 ; 17(6):1317-1330.
  • 8王芳,邓新粮.新辅助化疗对不同分型HPV宫颈癌近期疗效的临床分析[J] .医药前沿,2013,(13):42-43,44.
  • 9Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics, 2002[J]. CA Cancer J Clin, 2005,55(2) ~ 74-108.
  • 10World Health Organization Reproductive Health and Research, Chronic Diseases and Health Promotion, et al. Comprehensive cervical cancer eontrol~ a guide to essential practiceEC~.Gene- va~ World Health Organization, 2006 ~ 15-22.

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