摘要
目的利用傅立叶光学相干断层扫描技术(Fourier-domain optical coherence tomography,FD-OCT)比较正常人、早期青光眼、进展期青光眼患者各部位视网膜神经纤维层(peripapillary retinal never fiber layer,pRNFL)厚度及黄斑区各部位神经节细胞复合体(macular ganglion cell complex,mGCC)厚度差异,评价并分析其在青光眼中的诊断能力分析各参数的诊断能力。方法选取正常人41例(56眼)为正常组,早期青光眼组患者36例(42眼),进展期青光眼组患者35例(39眼),使用FD-OCT测量pRNFL及mGCC厚度,并对数据进行统计学分析,受试者曲线下面积(area under receive operated curve,AROC)。分析各参数的诊断能力。结果青光眼组各部位pRNFL厚度及mGCC厚度值随青光眼的严重程度逐渐减小,各参数的差异均有显著统计学意义(均为P<0.01)。正常组、早期青光眼组及进展期青光眼组平均、下方的mGCC与pRNFL具有相关性(r值分别为0.433、0.693、0.615、0.833、0.725、0.818;0.840、0.658、0.904;均为P<0.01)。早期青光眼组与正常组相比,除鼻侧象限之外(P=0.102),其余颞侧、上方、下方pRNFL及所有mGCC参数的AROC差异均有统计学意义(均为P<0.01)。对于总体青光眼(早期及进展期青光眼)与正常组比较发现,所有pRNFL及mGCC参数的AROC值差异均有统计学意义(pRNFL:0.941±0.020,mGCC:0.920±0.022,P<0.01)。所有pRNFL与mGCC参数之间的诊断能力差异无统计学意义(均为P>0.05)。结论 mGCC厚度与pRNFL厚度的检测在青光眼早期诊断能力中具有可比较性。黄斑区GCC厚度的测量对RNFL在临床青光眼诊断中是一个很好的补充检查手段。
Objective To obtain the difference between the thickness of macular ganglion cell complex（mGCC） and retinal never fiber layer （pRNFL） in healthy men, patients with early manifest glaucoma （EMG）, and patients with glaucomaevolutum u- sing Fourier-domain optical coherence tomography （ FD-OCT）, and then evaluate and analyze the diagnosibility of it and other parameters for glaucoma. Methods 41 healthy men（55 eyes） ,35 patients（42 eyes） with EMG and 35 patients with glaucomae- volutum were recruited as normal group, EMG group and glaucomaevolutum group, re- spectively. The thicknesses of mGCC and pRNFL were measured using FD-OCT, and the parameters were analyzed statistically. Area under receiver operating characteristic curve （AUROC） of the parameters were also obtained. Then diagnobility of the parame- ters were analyzed. Results The thicknesses of mGCC and pRNFL at all parts gradu- ally decreased as glaucoma degree aggravating, all parameters were significantly differ- ent from each other（ All P 〈 0.01 ）. The superior, average and inferior thicknesses of mGCC were correlated with those of pRNFL in all three groups（ r = 0. 443,0. 593,0. 515, 0. 833 ,0. 725 ,0. 818 ,0. 840,0. 558 and 0.904, respectively） （ All P 〈 0.01 ）. AUROC of all pRNFL and mGCC parameter but nasal pRNFL thickness （P = 0. 102 ） of normal groupand EMG group were significantly different from each other（ All P 〈 0.01 ）. AUROC of all pRNFL and mGCC parameters of normal group and glaucoma group （two glaucoma groups） were significantly different from each other （pRNFL： 0. 941 ± 0. 020, mGCC ：0.920 ± 0.022, All P 〈 0.01 ）. The diagnosibility of all pRNFL and mGCC parameters were not significantly dif- ferent from each other （All P 〉 0. 05 ） Conclusion The diagnosibility of pRNFL and mGCC thickness for EMG were com- parable. The measurement of mGCC thickness is a good supplementarv examination to DRNFL thickness measurement.
出处
《眼科新进展》
CAS
北大核心
2013年第9期843-846,共4页
Recent Advances in Ophthalmology
基金
河南省科技厅项目(编号:112102310212)~~
关键词
FD-OCT
视网膜神经节复合体
视网膜神经纤维层
青光眼
Fourier-domain optical coherence tomography
macular ganglion cellcomplex
retinal never fiber layer
glaucoma
