摘要
目的探讨脑电图（EEG）和MR弥散加权成像（DWI）对皮质-纹状体-脊髓变性（CJD）的诊断价值。，方法对3例CJD患者的临床资料进行回顾性分析。结果3例患者均为亚急性起病，出现智能、意识障碍及锥体柬、小脑损害的症状。腰穿CSF检查常规、生化均正常。早期头颅CT或常规MRI检查无异常各1例。3例患者（1例在发病7d后第3次）EEG检查均表现为典型的周期性三相波或周期性脑波。头部MRDWI示人脑皮质或放射冠、半卵圆中心、基底节区、丘脑呈高信号。1例患者行右额颞部脑组织活检确诊。3例患蕾在发病后1～3个月死亡。结论EEG和MRDWI对CJD有重要的诊断作用，尤其MRDWI对早期CJD有较高的诊断价值。
Objective To explore the diagnostic value of electroencephalogram （EEG） and MR diffusion weighted imaging（DWI） on Crentzfeldt-Jakob disease （CJD）. Methods The clinical data of 3 CJD patients were analyzed retrospectively. Results Three patients were subacute onset and the symptomas included disturbance of intelligence, consciousness, pyramidal damage and cerebellar damage. CSF routine and biochemical of 3 patients with lumbar puncture check were normal. Early brain CT or MR1 showed abnormal in 1 case respectively. EEG of 3 patients （ 1 patient onset of 7 d, the third times） all showed the typical periodic three-phase waves or periodic waves. Brain MR DWI examination showed the high signal in eerebral cortex or corona radiata, centrum semiovale, basal ganglion, thalamus in the early stage. One patient was diagnosis with right frontal temporal brain tissue biopsy. After the onset of 1 -3 months, 3 patients died. Conclusion EEG and MR DWI play an important role in diagnosis of CJD. Especially MR DWI has a higher diagnostic value in early CJD patients.
出处
《临床神经病学杂志》
CAS
北大核心
2013年第4期309-311,共3页
Journal of Clinical Neurology
