摘要
目的观察低分子肝素在治疗重症急性胰腺炎的临床疗效。方法将80例重症急性胰腺炎的患者随机分为研究组和对照组,各40例,研究组采用低分子肝素治疗,对照组采用常规治疗,疗程2周。于治疗前及治疗后1、3、7 d监测各组凝血功能及动脉血氧分压(PaO2),并每日监测体温、腹痛、腹部压痛及反跳痛等情况。结果经过2周治疗,两组显效率比较,研究组为82.5%,对照组为57.5%,有效率比较,研究组为95.0%,对照组为80.0%。两组间疗效比较差异有统计学意义(P<0.05)。研究组凝血指标较对照组无明显差异(P>0.05),PaO2变化较对照组明显改善(P<0.05);研究组治愈天数为10.43±3.69 d,对照组治愈天数为15.39±4.58 d,两组比较差异有统计学意义(P<0.05);两组手术率比较没有统计学意义(P>0.05),研究组病死率明显低于对照组,差异有统计学意义(P<0.05);两组均未发现消化道出血、腹腔出血或颅内出血等严重并发症。结论低分子肝素在治疗重症急性胰腺炎中疗效明显,能提高重症急性胰腺炎患者的临床疗效,降低病死率。
Objective To observe the effect of low molecular weight heparin in treatment of severe acute pancreatitis （SAP）. Methods A total of 80 patients with severe acute pancreatitis were randomly divided into study group （ n = 40） and control group （ n = 40）, patients in study group were treated with low molecular weight heparin （LMWH） and patients in control group were treated with routine therapy, and the treatment course was 2 weeks in both groups. Coagulation function and Pa02 were examined before treatment and 1,3 and 7 days after treatment, and their body temperature, abdominal pain, abdominal tenderness and rebounding pain etc were monitored every day in patients of both groups, and they were compared after treatment for 2 weeks. Results After treatment for 2 weeks, the difference in effective rate between these 2 groups was significant, the effective rate in study group was 92.5%, and it in control group was 82.5% ; and the difference between these two groups was significant （ P 〉 0.05 ）. In comparison with routine treatment, LMWI-I could significantly increase the blood oxygen saturation, meanwhile LMWH could reduce the mortality rate as well as decrease the incidence of complications and cut down the possibility of surgery in SAP patients, while it had a tiny impact on coagulation function compared with RT group. Conclusion LMWH can enhance the therapeutic effect and improve the prognosis of patients with severe acute pancreatitis.
出处
《临床和实验医学杂志》
2013年第18期1459-1461,共3页
Journal of Clinical and Experimental Medicine
关键词
重症急性胰腺炎
低分子肝素
疗效
Severe acute pancreatitis
Low molecular weight heparin
Effect
