摘要
目的探讨伐地那非治疗急性肺血栓栓塞症(APTE)的疗效及可行性。方法选用日本大耳纯种家兔36只,随机分为4组,每组9只,分别为空白对照组、APTE模型组、伐地那非低剂量组、伐地那非高剂量组。对家兔进行急性肺血栓栓塞症造模,APTE组无药物干预;伐地那非低剂量组:予伐地那非片1.5 mg/kg治疗;伐地那非高剂量组:予伐地那非片3.0 mg/kg治疗。测定家兔栓塞后各时间点(0 h,1 h,2 h,4 h)的动脉血气、肌钙蛋白(cTnI)、N端前脑钠肽(NT-proBNP)、右室收缩压(RVSP)、平均动脉压(MAP)并比较各组数据。结果 APTE模型组与伐地那非低、高剂量组检验结果差异均具有统计学意义(P<0.05);伐地那非低、高剂量组检验结果差异具有统计学意义(P<0.05)。结论伐地那非可改善急性肺血栓栓塞家兔的动脉血气、NT-proBNP、cTnI及血流动力学指标,对肺栓塞有一定的治疗效果。
Objective To investigate the therapic effect and feasibility of vardenafil in the treatment of acute pul- monary thromboembolism（APTE）. Methods A total of 36 Japan large ear purebred rabbits were randomly divided into 4 groups, respectively for the control group, the APTE model group, the low-dose vardenafil group, the high-dose var- denafil group, and each group had 9 rabbits. The APTE model of rabbits were made. The APTE model group were giv- en non-drug intervention, while the low-dose vardenafil group were given 1.5 mg/kg vardenafil treatment, and the high-dose vardenafil group were given 3.0 mg/kg vardenafil treatment. The arterial blood gas, cardiac troponin I（cTnI）, N-terminal pro B-type natriuretic peptide （NT-proBNP）, right ventricular systolic pressure （RVSP）, mean arterial pres- sure（MAP） of rabbits at 0 h, 1 h, 2 h and 4 h after transarterial chemoembolization were determined and compared. Results The differences were statistically significant in examination results among the APTE model group, the low- dose vardenafil group and the high-dose vardenafil group （P〈0.05）. There were significant differences in examination results between the low-dose vardenafil group and the high-dose vardenafil group （P〈0.05）. Conclusion Vardenafil can im prove the arterial blood gas, NT-proBNP, cTnI and hemodynamics indexes of acute pulmonary thromboembolism rabbits, and has some therapic effect for pulmonary embolism.
出处
《中国现代医生》
2013年第25期10-13,共4页
China Modern Doctor
基金
浙江省温州市2012年第二期科技计划项目(Y20120178)
关键词
急性肺血栓栓塞
5型磷酸二酯酶抑制剂
伐地那非
Acute pulmonary thromboembolism
Type-5 phosphodiesterase inhibitor
Vardenafil
