摘要
目的探讨大剂量氨溴索注射液治疗慢性支气管炎急性发作的临床疗效。方法选择本院近年收治的慢性支气管炎急性发作患者108例,随机分为研究组、对照组。两组均予常规治疗。研究组在常规治疗基础上给予盐酸氨溴索注射液30 mg+5%葡萄糖溶液250 mL静脉滴注,3次/d。对照组给予盐酸氨溴索注射液7.5mg+5%葡萄糖溶液250 mL静脉滴注,3次/d。两组均治疗7～10 d,观察治疗效果、两组症状体征消失时间及CRP、IL-8、TNF-α变化情况。结果症状体征消失时间研究组明显短于对照组,差异有统计学意义(P<0.05);治疗后两组CRP、IL-8、TNF-α均降低,但研究组明显低于对照组,差异有统计学意义;研究组总有效率为92.6%,对照组总有效率为74.1%,研究组明显高于对照组,差异有统计学意义(P<0.05)。结论大剂量氨溴索注射液辅助治疗慢性支气管炎急性发作效果良好,症状缓解快,安全性高,值得临床应用。
Objective To investigate the efficacy of large dose of ambroxol in the treatment of AECB.Methods One hundred and eight cases of AECB patients were randomly divided into study group and control group.The patients of two groups were all given conventional treatment.On the basis of conventional treatment,patients in the study group were given ambroxol hydrochloride injection 30 mg ＋5% glucose solution 250 mL intravenous infusion,3 times/d;patients in the control group were given ambroxol hydrochloride injection 7.5 mg ＋5% glucose solution 250 mL intravenous infusion,3 times/d.They were all treated for 7 to 10 days.The treatment effect,signs and symptoms extinction time,CRP,IL-8,TNF-α changes of two groups were observed.Results The symptoms and signs extinction time of study group were significantly shorter than control group,the difference was statistically significant（P 0.05）;CRP,IL-8,TNF-α of two groups were all reduced after treatment,but the CRP,IL-8,TNF-α level of study group was significantly lower than control group,the difference was statistically significant;The total effective rate of study group and control group were 92.6% and 74.1%,the difference between the two groups was statistically significant（P 0.05）.Conclusion The effect of large dose of ambroxol injection in adjuvant treatment of AECB is good,the symptoms extinction time is short,the safety is high,so it is worthy of clinical application.
出处
《中国现代医生》
2013年第25期36-37,39,共3页
China Modern Doctor
关键词
氨溴索
慢性支气管炎
急性发作
炎性因子
Ambroxol
Chronic bronchitis
Acute episode
Inflammatory factors
