摘要
目的研究应用白介素-11与重组人血小板生成素联合对化疗后出现血小板减少症状的白血病患者实施治疗的临床效果。方法抽取72例化疗后出现血小板减少症状的白血病患者,随机分为对照组和治疗组,每组各36例。采用白介素-11对对照组患者实施治疗;采用白介素-11与重组人血小板生成素联合对治疗组患者实施治疗。结果对照组患者经治疗后,治愈9例,有效15例,无效12例,血小板减少症状治疗总有效率为67.7%;治疗组患者治疗后,治愈14例,有效19例,无效3例,治疗总有效率为91.7%。治疗组患者血小板减少症状治疗效果明显优于对照组。对照组患者经(13.68±2.41)d治疗后血小板水平恢复正常,共计用药治疗(17.54±2.75)d;治疗组患者经(9.62±2.95)d治疗后血小板水平恢复正常,共计用药治疗(13.25±2.13)d。血小板水平恢复正常时间和用药治疗总时间明显短于对照组。结论应用白介素-11与重组人血小板生成素联合对化疗后出现血小板减少症状的白血病患者实施治疗的临床效果非常明显。
Objective To study about the clinical efficacy of recombinant human thrombopoietin combine with Inter- leukin- 11 treatment to thromboeytopenia after chemotherapy of leukemia. Methods 72 patients with thrombocytopenia after chemotherapy of leukemia were selected and randomly divided into control group and treatment group with 36 pa- tients in each group.Patients in the control group were given Interleukin-11 treatment while patients in the treatment group were given recombinant human thrombopoietin combine with Intedeukin-11 treatment. Results In the control group,9 patients were cured,15 cases were effective while 12 cases were ineffective after treatment,the total treatment efficiency of thrombocytopenia symptoms was 67.7%;In treatment group,14 patients were cured,19 cases were effective while 3 cases were ineffective after treatment,the total treatment efficiency of thrombocytopenia symptoms was 91.7%. Treatment group had a significantly better clinical efficacy of the treatment to thrombocytopenia in comparison with the control group.The control group of patients took （13.68±2.41） d after treatment to have platelet levels return to normal with a total drug treatment of （17.54±2.75） d; the treatment group of patients took （9.62±2.95） d treatment to have platelet levels return to normal with a total drug treatment of （13.25±2.13） d.The time for platelet level to return to normal and the total time of drug treatment of treatment group were significantly shorter than the control group. Con- clusion Recombinant human thrombopoietin combine with Interleukin-11 treatment has sound efficacy to treat throm- bocytopenia after chemotherapy of leukemia.
出处
《中国当代医药》
2013年第25期63-64,共2页
China Modern Medicine
