摘要
目的对现有的关于百令胶囊对于肾病综合征成人患者的治疗作用的文献进行Meta分析,为临床实践提供依据。方法通过Pubmed、中国生物医学文献数据库、中国期刊全文数据库等数据库检索,选取相关文献。提取效应尺度指标相关数据进行定量Meta分析或定性描述。结果共纳入5篇文献。Meta分析结果显示百令胶囊能够降低肾病综合征患者的24 h尿蛋白[SMD=2.35(3.72,0.97),P<0.01],提高血清白蛋白水平[SMD=0.94(0.37,1.52),P=0.01],但对于血肌酐[SMD=0.50(1.25,0.26),P=0.20]及血尿素氮[SMD=0.10(0.36,0.17),P=0.48]的水平没有明显的改善作用。此外,其中有两个研究报道了百令胶囊能够降低血总胆固醇、甘油三酯及低密度脂蛋白。结论百令胶囊的辅助治疗能够进一步减少肾病综合征患者的蛋白尿,提高血浆白蛋白水平,且可能能够降低患者血脂。但这些结论需要进一步临床试验证实。
OBJECTIVE To perform Meta-analysis of published articles on the efficacy of Bailing capsules for adult patients with primary nephrotic syndrome（PNS） and provide evidence for clinical practice. METHODS We searched Pubmed, CBM, CNKI and other databases to identify eligible articles and extract effect measure-related data to perform Meta-analysis. And qualitative description was also conducted for those unable to be combined. RESULTS Five records were selected. The results of Meta-analysis showed that Bailing capsules could reduce proteinuria [SMD=-2.35（-3.72, -0.97）, P〈0.01 ] and improve serum albumin [SMD=0.94 （0.37, 1.52）, P=0.01] in PNS patients. However, Bailing capsules adjuvant therapy had no effect on serum creatinine [SMD=-0.50（-1.25, 0.26）,P=0.20] and urea nitrogen level [SMD=-0.10（-0.36, 0.17）, P=0.48]. Additionally, two studies reported that Bailing capsules could lower serum cholesterol, triglyceride and low density lipoprotein.CONCLUSION Addition of Bailing capsules could decrease proteinuria and enhance serum albumin in PNS patients. Suggestive evidence showes Bailing capsules adjuvant therapy can correct dyslipidemia in these patients. However, these conclusions should be further validated in future clinical trials.
出处
《中国现代应用药学》
CAS
CSCD
2013年第8期907-910,共4页
Chinese Journal of Modern Applied Pharmacy
关键词
百令胶囊
肾病综合征
蛋白尿
META分析
Bailing capsule
primary nephrotic syndrome
proteinuria
Meta-analysis
