摘要
目的调查老年女性宫颈病变与人乳头状瘤病毒(HPV)感染的相关性,为临床防治提供策略。方法将2007年4月-2012年4月在医院诊治的623例老年女性按病理组织检查结果分为正常组(173例)、炎症组(157例)、低度鳞状上皮细胞内瘤变组(130)、高度鳞状上皮细胞内瘤变组(100)和宫颈癌组(73例)共5组,比较5组患者的HPV感染及老年宫颈病变与HPV感染的相关性。结果正常组、炎症组、低度鳞状上皮细胞内瘤变组、高度鳞状上皮细胞内瘤变组及宫颈癌组HPV感染率,分别为9.25%、15.29%、57.69%、74.00%及87.67%,经卡方检验,组间差异有统计学意义(P<0.05);HPV感染率与宫颈病变程度的相关系数r=0.972,呈正相关。结论老年女性宫颈病变的严重程度随HPV感染概率的增高而加重,两者存在明显的相关性。
OBJECTIVE To investigate the correlation between the cervical lesions in elderly female patients and the human papilloma virus （HPV） infections so as to guide the clinical prevention. METHODS A total of 623 cases of elderly female patients with cervical lesions who were treated in the hospital from Apr, 2007 to Apr, 2012 were divided into the normal group （173 cases ）, the inflammation group （157 cases）, the low-grade squamous epitheli- al cells of tumor variable group （130 cases）, and the highly squamous epithelial cells of tumor variable group （100 cases ） and the cervical cancer group （73 cases） according to the histopathological examiantion findings, then the incidence of HPV infections was compared between the five groups, and the correlation between the cervical lesion and the HPV infections was analyzed. RESULTS The incidence rate of HPV infections was 9.25% in the normal group, 15.29 % in the inflammation group , 57.69 % in the low-grade squamous epithelial cells of tumor variable group, 74.00% in the highly squamous epithelial cells of tumor variable group, and 87. 67% in the cervical cancer group, the chi-square test showed that the difference was statistically significant （P〈0.05）. The positive correla- tion coefficient for HPV infection rate and cervical lesions was 0. 972. CONCLUSION The increase of the incidence of HPV infections may result in more serious cervical lesions in the elderly female patients, and there is significant correlation between the two.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第15期3682-3683,3686,共3页
Chinese Journal of Nosocomiology
基金
河南省医学科技攻关项目(201003030)
关键词
人乳头状瘤病毒
感染
宫颈病变
相关性
Human papilloma virus
Infection
Cervical lesion
Correlation
