摘要
目的研究血浆可溶性髓样细胞触发受体-1在脓毒症诊断中的价值。方法检索PubMed、Ovid、Springer数据库、万方数据库中1991年到2012年国内外公开发表的关于血浆可溶性髓样细胞触发受体-1诊断脓毒症的相关文献，根据纳入和排除标准筛选文献并提取可用数据，通过Meta—DiSc及Stata软件进行Meta分析。结果根据纳入标准筛选出7篇文献，各个研究截断值差异较大。异质性检验表明资料存在异质性（I^2〉50％，P〈0．05），采用随机模型合并诊断指标。合并后的灵敏度81％，95％CI：0．76～0．86；特异度81％，95％CI：0．76—0．86；诊断优势比30．03，95％CI：7．89～114．37，SROC曲线的曲线下面积为0．9059，Q^＊指数为0．8376。Deek漏斗图显示无明显发表偏倚。结论血浆可溶性髓样细胞触发受体一l用于脓毒症诊断具有一定的临床价值，但诊断脓毒症的最佳截断值有待进一步研究。
Objective To investigate the value of plasma soluble triggering receptor expressed on myeloid cells-1 as a diagnosis marker of sepsis. Methods Articles on plasma soluble triggering receptor expressed on myeloid cells-1 as a marker of sepsis which were public published in the PubMed, Ovid, Springer, Wanfang database from 1991-2012 were searched and conducted a meta-analysis by MetaDiSc and Stata. Results Seven articles were selected to the meta-analysis according to the inclusion criteria, of which cut-off values varied signicantly from studies. Due to the data heterogeneity （I= 〉 50% , P 〈 0. 05） , random model was used to pool the effect sizes. The overall combined effect sizes： sensitivity = 81% （95% CI ： 0.76-0.86）; specificity = 81% （95% CI： 0.76 -0.86）; DOR = 30. 03 （95% CI： 7.89 - 114. 37） ; AUC of SROC = 0. 905 9; Q＊ = o. 837 6. Deck＇ s funnel plot showed little publication bias. Conclusions Plasma soluble triggering receptor expressed on myeloid cells-1 may be a useful adjunctive tool for the diagnosis of sepsis. However, further studies are needed in order to identify the best cut-off value in the diagnosis of sepsis.
出处
《中华急诊医学杂志》
CAS
CSCD
北大核心
2013年第9期1025-1029,共5页
Chinese Journal of Emergency Medicine
关键词
可溶性髓样细胞触发受体-1
脓毒症
诊断
血浆
C反应蛋白
降钙素原
META分析
截断值
Soluble triggering receptor expressed on myeloid cells-1 （sTREM-1）
Sepsis
Diagnosis
Plasma
C-reaction protein
Procalcitonin
Meta-analysis
Cut-off value
