摘要
染色质重塑是真核生物表观遗传调控的重要方式.通过对染色质物理结构的调节,染色质重塑在高等动植物干细胞的自我更新及分化、器官和个体发育以及肿瘤发生等多种生物学过程中发挥重要作用.近年来,高等动植物染色质重塑方面的研究已经成为表观遗传学研究领域的热点.本综述总结近年来有关高等动植物染色质重塑的重要研究报道,介绍了染色质重塑的结构机制、分析比较了高等动植物染色质重塑复合体的组成及其生物学功能的多样性,并着重综述了高等植物SWI/SNF染色质重塑复合体各组分在调控植物发育与逆境生长等方面的功能,以期为今后植物中染色质重塑的研究提供启示.
As one of the epigenetic regulation mechanisms,ATP-dependent chromatin remodeling participates in various critical biological processes,including stem cell maintenance and differentiation,individual development,and other physiological and pathological processes in higher plants and animals.Recently,studies on chromatin remodeling have become one of hot fields in epigenetics.In this review,based on the recent progresses in the field of chromatin remodeling in higher plants and animals,we summarized the mechanisms of chromatin remodeling,and analyzed the diversity of the compositions and biological functions of chromatin remodeling complexes in higher plants and animals.Significantly,the function of SWI/SNF chromatin remodeling complexes in plant development under normal and environmental stress was emphatically summarized.This review will be helpful to understand the molecular mechanisms of the chromatin remodeling in plants.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2013年第9期804-812,共9页
Progress In Biochemistry and Biophysics
基金
国家自然科学基金面上项目(31171170)
河北省杰出青年基金项目(C2009001516)资助~~
