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右美托咪啶在老年膝关节置换术中的应用 被引量:9

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摘要 硬膜外麻醉是膝关节置换手术常用的麻醉方式,但术中知晓增加了患者的心理压力和恐惧,容易诱发高血压、心律失常等严重并发症,而使用静吸复合全麻,管理复杂、并发症多,如何合理选择药物既能进行适当的镇静镇痛,减少对呼吸循环系统的影响,又能消除患者在麻醉和手术过程中的不良记忆,具有重要的意义。右美托咪啶(DEX)因其具有镇静、镇痛、抗焦虑、降血压作用而逐渐应用于手术麻醉中。本研究拟通过使用不同剂量不同方法的EDX辅助硬膜外麻醉用于老年膝关节置换手术,观察其镇痛镇静及遗忘效果,为临床应用提供依据。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2013年第17期4310-4311,共2页 Chinese Journal of Gerontology
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参考文献6

  • 1Somers M J, Mavromatis K, Galis ZS, et al. Vascular superoxide production and vasomotor function in hypertension induced by deoxycorticosterone ac- etate-salt[ J]. Circulation,2000 ; 101 (4) : 1722-8.
  • 2Shehabi Y, Ruettimann U, Adamson H, et al. Dexmedetomidine infusion for more than 24 hours in critically ill patients:sedative and cardiovascu- lar effects[ J]. Intensive Care Med,2004;30(12) :2188.
  • 3何征宇,王祥瑞.右旋美托嘧啶在术后谵妄防治中的应用[J].临床麻醉学杂志,2010,26(4):361-363. 被引量:51
  • 4李民,张利萍,吴新民.右美托咪啶在临床麻醉中应用的研究进展[J].中国临床药理学杂志,2007,23(6):466-470. 被引量:483
  • 5Hall JE, Uhrich TD, Barney JA, et al. Sedative, amnestic, and analgesic properties of small-dose dexmedetomidine infusions [ J]. Anesth Analg, 2000 ;90 ( 3 ) :699-705.
  • 6Groeben I-I, Mitzner W, Brown RH. Effects of the alpha 2-adrenoceptor ag- onist dexmedetomidine on bronchoconstriction in dogs [J]. Anesthesiolo- gy,2004 ; 100(2) :395-63.

二级参考文献52

  • 1[1]Khan ZP,Ferguson CN,Jones RM.Alpha-2 and imidazoline receptor agonists:their pharmacology and therapeutic role[J].Anesthesia,1999;54:146-165.
  • 2[2]Kamibayashi T,Maze M.Clinical uses of alpha 2-adrenergic agonists[J].Anesthesiology,2000;93:1345-1350.
  • 3[3]Calzada BC,De Artinano AA.[alpha]2-Adrenoreceptor subtypes[J].Pharmacol Res,2001;44:195-208.
  • 4[4]Hunter JC,Fontanna DJ,Hedley LR,et al.Assessment of the role of alpha 2-adrenoceptor subtypes in the antinociceptive,sedative and hypothermic action of dexmedetomidine in transgenic mice[J].Br J Pharmacol,1997;122:1339-1344.
  • 5[5]Nelson LE,Lu J,Guo TZ,et al.The α2-Adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects[J].Anesthesiology,2003;98:428-436.
  • 6[6]Coull JT,Jones M,Egan T,et al.Attentionla effects of noradranaline vary with arousal level:selective activation of thalamie pulvinar in humans[J].Neuro Image,2004;22:315-322.
  • 7[7]Eisenach JC.[Alpha]2 agonists and analgesia[J].Exp Opin Invest Drugs,1994;3:1005-1010.
  • 8[8]Ma D,Rajakumamswamy N,Maze M.Alpha2-Adrenoceptor agonists:shedding light on neuroprotection?[J].Br Med Bull,2005;71:77-92.
  • 9[9]Ebert TJ,Hall JE,Barney JA,et al.The effects of increasing plasma concentrations of dexmedetomidine in humans[J].Anesthesiology,2000;93:382-394.
  • 10[10]Ramsey MA,Luterman DL.Dexmedetomidine as a total intravenous anesthestic agent[J].Anesthesiology,2004;101:787-781.

共引文献530

同被引文献97

  • 1李民,张利萍,吴新民.右美托咪啶在临床麻醉中应用的研究进展[J].中国临床药理学杂志,2007,23(6):466-470. 被引量:483
  • 2Allen KD, Golightly YM, Callahan LF, et al. Racial and gender differenees in willingness to undergo total ioint replacement The Johnston County Osteoarthritis Profect[J].Arthritis Care Res Hoboken,2014.[Epub ahead of print].
  • 3Bergin C, Speroni KG, Travis T, etal. Effect of preoperative incentive spirometry patient education on patient outcomes in the knee and hip joint replacement population[J]. J Perianesth Nurs,2014, 29(1): 20-27.
  • 4Kanda H, Kunisawa T, Kurosawa A, et al.Effect of dexmedetomidine on anesthetic requirements in cardiovascular surgery[J].Masui,2009,58 ( 12 ) : 1496-1500.
  • 5A. Simon Harvey,Jeffrey V. Rosenfeld.What happens to cognitive function following surgery for hypothalamic hamartoma?[J]. Neurology . 2013 (12)
  • 6George Djaiani,Rita Katznelson,Ludwik Fedorko,Vivek Rao,Robin Green,Jo Carroll,Jacek Karski.Early benefit of preserved cognitive function is not sustained at one-year after cardiac surgery: a longitudinal follow-up of the randomized controlled trial[J]. Canadian Journal of Anesthesia/Journal canadien d’anesthésie . 2012 (5)
  • 7Unterrainer AF,Uebleis FX,Gross FA,et al.TENS compared to opioids in postoperative analgesic therapy after major spinal surgery with regard to cognitive function. Middle East Journal of Anesthesiology . 2012
  • 8Han C,Ding W,Jiang W,et al.A comparison of the effects of midazolam,propofol and dexmedetomidine on the antioxidant system:A randomized trial[J].Exp Ther Med,2015,9(6):2293-2298.
  • 9刘志学.麻醉药物在心肌缺血预处理中的作用[J].中国中西医结合外科杂志,2008,14(1):79-80. 被引量:1
  • 10刘沁,仓静,薛张纲.膝关节镜手术腰麻与喉罩全麻的成本-效益分析[J].浙江临床医学,2010,12(2):206-207. 被引量:2

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