摘要
目的 研究血管内皮生长因子 (VEGF)在乳腺癌的发生及判断预后方面的意义。方法 应用S P免疫组化染色法检测VEGF在乳腺良恶性病变中的表达。结果 乳腺癌VEGF表达阳性率 (72 .5 % )高于乳腺良性病变 (2 /8) ,二者间差异具有显著性 (P <0 .0 5 )。 40例乳腺癌中 ,淋巴结转移组VEGF阳性表达 (19/ 2 1)高于无淋巴结转移组(12 / 19) ,二者差异具有显著性 (P <0 .0 5 )。结论 VEGF在乳腺癌发生及判断预后方面具有重要意义。
Objective To study the role of vascular endothelial growth factor (VEGF) in development and evaluating prognosis of breast cancer. Methods S P immunohistochemical method was used to detect VEGF expression in breast benign and malignant disease. Results VEGF expression positive rate in breast cancer (72.5%) was higher than that in breast benign disease (2/8), the difference was significant ( P <0.05). In 40 cases of breast cancer, the expression of VEGF in lymphatic metastasic group (19/21) was more than that in none lymphatic metastasic group(12/19), the difference was significant ( P <0.05). Conclusion VEGF play an important role in development and evaluating prognosis of breast cancer.
出处
《哈尔滨医科大学学报》
CAS
2000年第5期341-342,共2页
Journal of Harbin Medical University
关键词
血管内皮生长因子
乳腺癌
免疫组化
基因表达
vascular endothelial growth factor
breast cancer
immunohistochemical method
