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120例恶性肿瘤患者检测细胞质胸苷激酶的临床分析 被引量:4

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摘要 目的:探讨肿瘤患者血清细胞质胸苷激酶(TK1)在临床应用上的意义。方法:利用免疫印迹增强化学发光法,检测120例肿瘤患者血清和20例健康体检者血清的TK1水平。结果:肿瘤患者TK1阳性率为45.28%,健康体检者血清TK1阳性率为5%。鳞癌TK1阳性率为26.08%,腺癌TK1阳性率为54.28%。其中乳腺肿瘤、消化道肿瘤、其他肿瘤TK1阳性率较高,分别达55.56%、62.50%、53.85%。肺部肿瘤及宫颈肿瘤的TK1阳性率较低,分别为12.50%、14.2%。结论:血清TK1检测在腺癌的辅助诊断上是一个有价值的标志物。
作者 房恩山
出处 《医学理论与实践》 2013年第17期2342-2343,共2页 The Journal of Medical Theory and Practice
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  • 1刘长仲,贺春贵.三种果树叶螨实验种群参数的分析[J].植物保护学报,1994,21(2):176-176. 被引量:3
  • 2He Q,Zou L,Zhang PA,et alThe clinical significance of thymidine kinase 1 measurement in serum of breast cancer patients using anti-TK1 antibody[J].Int J Biol Markers,2000,15(2):139-146.
  • 3Zou L,Zhang PG,Zou S,et al.The half-life of thymidine kinase 1in serum measured by ECL dot blot:a potential marker for monitoring the response to surgery of patients with gastric cancer[J].Int J Biol Markers,2002,17(2):135-140.
  • 4He Q,Zou L,Zhang PA,et al.Concentration of thymidine kinase 1 in serum (S-TK1) is a more sensitive proliferation marker in human solid tumors than its activity[J].Oncol Rep,2005,14(4):1013-1019.
  • 5Zhang J,Jia Q,Zou S,et al.Thymidine kinase 1:a proliferation marker for determining prognosis and monitoring the surgical outcome of primary bladder carcinoma patients[J].Oncol Rep,2006,15(2):455-461.
  • 6Kauffman MG,Kelly TJ.Cell cycle regulation of thymidine kinase:residues near the carboxyl terminus are essential for the specific degradation of the enzyme at mitosis[J].Mol Cell Biol,1991,11(22):2583-2546.
  • 7He Q,Wang N,Skog S,et al.Characterization of a peptide antibody against a C-terminal part of human and mouse cytosolic thymidine kinase,which is a marker for cell proliferation[J].Eur J Cell Biol,1996,70(2):117-124.
  • 8Gronowitz JS,Hagberg H,Kallander CF,et al.The use of serum deoxythymidine kinase as a prognostic marker,and in the monitoring of patients with non-Hodgkin's lymphoma[J].Br J Cancer,1983,47(4):487-495.
  • 9Gronowitz JS,Bergstr?m R,N?u E,et al.Clinical and serologic markers of stage and prognosis in small cell lung cancer.A multivariate analysis[J].Cancer,1990,66(4):722-732.
  • 10Bresnick E,Mayfield ED Jr,Liebelt AG,et al.Enzyme patterns in a group of transplantable mouse hepatomas of different growth rates[J].Cancer Res,1971,31(6):743-751.

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  • 1顾光大.血清胃蛋白酶原、胸苷激酶联合检测对胃癌的诊断意义[J].实用医学杂志,2009,25(5):715-717. 被引量:14
  • 2Zhang F, Li H, Pendleton AR, et al. Thymidine kinase 1 i mmuno- assay:a potential marker for breast cancer [ J ]. Cancer Detect Prey,2001,25( 1 ) :8 - 15.
  • 3Kemik O,Kemik AS,Purisa S,et al. Serum thymidine kinase is as- sociated with gastric adenocarcinoma[ J]. Bratisl Lek Listy ,2011, 112(9) :510 -511.
  • 4Huang S, Lin ], Guo N, et al. Elevated serum thymidine kinase 1 predicts risk of pre/early cancerous progression [ J ]. Asian Pac J Cancer Prev,2011,12 (2) :497 - 505.
  • 5Li ZS, WangYH, MaJ, et al. Transient increase in serum thymidine kinase 1 within one week after surgery of patients with carcinoma [ ]]. Anticancer Res,2010,30(4) :1295 - 1299.
  • 6Skog S, Tribukait B. Irradiation induced cell death as related to cell eyelc [ J ]. Acta Radiol Oncol, 1985,24 ( 1 ) : 87 - 93.
  • 7He QM,Zhang P, Li Z, et al. Concentration of thymidine kinase 1 in serum( S- TK1 )is a more sensitive proliferation marker in hu- man solid tumors than its activity[ J]. Ontology Reports,2005,14 (4) :1013 -1019.
  • 8Li ZS, Wang YH, Ma J, et al. Serological thymidine kinase 1 is a prognostic factor in oesophageal, cardial and lung carcinomas [ J ]. European Journal of Cancer Prevention, 2010,19 (4) : 313 - 318.
  • 9Chen Y,Ying M, Chen Y, et al. Serum thymidine kinase 1 corre-lates to clinical stages and clinical reactions and the outcome of therapy of 1247 cancer patients in routine clinical settings[ J]. Int J Clin Onco1,2010,15 (4) :359 - 368.
  • 10曹秀峰,吕进,朱斌,安红银,王山,吴必超,纪律,陶磊,王冬冬.局部晚期食管鳞状细胞癌术后放疗和化疗的前瞻性研究[J].中华肿瘤杂志,2010,32(6):452-455. 被引量:39

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