摘要
目的 研究在中国人中三唑仑 (triazolam)片的血药浓度测定方法及药代动力学。方法 8名健康男性志愿者 ,单次服用0 .5mg三唑仑片 ,在不同时间点取静脉血 ,血浓度采用气相色谱色谱法 (GC)测定。药代动力学参数采用 3P87程序计算。结果 三唑仑片的主要药代动力学参数Ka ,AUC0～ 7,cmax,tmax,t1/ 2 ,CL/F分别为 (2 .33± 0 .84)h-1,(11.0 0± 3.75 )ng·h·ml-1,(3.95± 0 .74)ng·ml-1,(0 .92± 0 .37)h ,(1.2 0± 0 .39)h ,(0 .0 49± 0 .0 17)L·h-1。结论 三唑仑片在体内能迅速吸收并很快消除 ,这与其临床作用是一致的。
OBJECTIVE To study the pharmacokinetics of triazolam tablet in 8 healthy male volunteers.METHODS Blood samples were obtained at 0,0.25,0.5,0.75,1,1.5,2,2.5,3,4,5,7 h after a single dose of 0.5 mg triazolam tablets.Triazolam Plasma concentration was deternined by GS NPD.The pharmacokinetics of triazolam were analysed by 3P87 program.RESULTS The main Pharmacokinetic parameters of triazolam were Ka(2.33±0.84) h -1 ,AUC 0～7 (11.00±3.75) ng·h·ml -1 ,c max ,(3.95±0.74) ng·ml -1 ,t max (0.92±0.37) h,t 1/2 (1.20±0.39) h,CL/f(0.049±0.017) L·h -1 ,respectively.CONCLUSIONS Triazolam could be absorbed rapidly and eleminated fast in human.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2000年第10期686-688,共3页
Chinese Pharmaceutical Journal
关键词
三唑仑
血药浓度
药代动力学
triazolam
blood concentration
pharmacokinetics
