3Boileau C, Amiable N, Martel-Pelletier J, at al. Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study [J]. Arthritis Res Ther, 2007, 9(6): R121.
4Lee CH, Butt YK, Wong MS, et al. A lipid extract of Perna canaliculus affects the expression of pro-inflammatory eytokines in a rat adjuvant-induced arthritis model [J]. Eur Ann Allergy Clin Immunol, 2008, 40(4): 148-153.
5Kevorkian L, Young DA, Darrah C, et al. Expression profiling of metalloproteinases and their inhibitors in cartilage [J]. Arthritis Rheum, 2004, 50(1): 131-41.
6Ahmed S, Wang N, Hafeez BB, et al. Extract inhibits IL- 1beta-induced expression of matrix metalloproteinases by inhibiting the activation of MAP kinases and NF-kappaB in human chondrocytes in vitro [J]. J Nutr, 2005, 135(9): 2096-2102.
7Klatt AR, Klinger G, Neumuller O, et al. TAK1 downregulation reduces IL-1beta induced expression of MMP13, MMP1 and TNF-alpha. Biomed Pharmacother[J], 2006, 60(2): 55-61.
8Tchetverikov I, Lohmander LS, Verzijl N, et al. MMP protein and activity levels in synovial fluid fi-om patients with joint injury, inflammatory arthritis, and osteoarthntis [J]. Ann Rheum Dis, 2005, 64(5): 694-698.
9Lee Y J, Lee EB, Kwon YE, et al. Effect of estrogen on the expression of matrix metalloproteinase (MMP)- 1, MMP-3, and MMP- 13 and tissue inhibitor of metalloproternase- 1 in osteoarthritis chondrocytes[J]. Rheumatol Int, 2003, 23(6): 282-288.
10American College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines. Guidelines for the management of rheumatoid arthritis: 2002 Update. Arthritis Rheum. 2002; 46(2): 328-346.
7Inazuka M,Tahira T,Horiuchi T,et al.Analysis of p53tumour suppressor gene somatic mutations in rheumatoid arthritis synovium[J].Rheumatology,2000,39(3):262-266.
8He YT,Ou AH,Yang XB,et al.Traditional Chinese medicine versus western medicine as used in China in themanagement of rheumatoid arthritis:a randomized,single-blind,24-week study[J].Rheumatol Int,2014,34(12):1647-1655.
9Zhang C,Jiang M,LüAP.Evidence-based Chinesemedicine for rheumatoid arthritis[J].J Tradit ChinMed,2011,31(2):152-157.