洛贝林对恩氟烷麻醉小鼠催醒效果的观察被引量：1

Observation on the awakening effect of lobeline on mice under enflurane anesthesia

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摘要目的观察洛贝林对恩氟烷麻醉小鼠的催醒效果.方法将36只小鼠随机分为6组：恩氟烷＋生理盐水组（A组）、恩氟烷＋洛贝林1 mg/kg组（B组）、恩氟烷＋洛贝林3 mg/kg（C组）、恩氟烷＋洛贝林5 mg/kg组（D组）、恩氟烷＋洛贝林10 mg/kg组（E组）、恩氟烷＋洛贝林15 mg/kg组（F组）;观察不同剂量的洛贝林对恩氟烷麻醉小鼠麻醉持续时间的影响.结果与A组相比,B、C、D组均对小鼠有催醒作用（P〈0.05）,其中D组的催醒效果最明显（P〈0.01）,而E、F组催醒效果不明显（P〉0.05）,B、C、D、E、F组中小鼠麻醉持续时间的差异无统计学意义.结论合适浓度的洛贝林对恩氟烷麻醉小鼠有催醒作用,未发现洛贝林对小鼠的催醒作用存在剂量依赖性. Objective To observe the awakening effect of lobeline on mice under enflurane anesthesia. Methods 36 mice were randomly allocated into 6 groups： NS ＋ enflurane group （group A） , enflurane ＋ lobeline 1 mg/kg group （ group B） , cnflurane ＋ lobeline 3 mg/kg group （ group C） , enflurane ＋ lobeline 5 mg/kg group （ group D） , enflurane ＋ lobeline 10 mg/kg group （group E） , and enflurane ＋ Lobeline 15 mg/kg group （group F）. The lasting time of en- flurane anesthesia after injection of different doses of lobeline was observed. Results Compared with group A, groups B, C, and D had a significant awakening effect （ P 〈 0.05 ）, while group D had the most obvious effect （ P 〈 0.01 ）. Groups E and F had no significant awakening effect （ P 〉 0.05 ）. There were no significant differences in the lasting time of enflurane anesthesia among groups B to F. Conclusion The proper concentration of lobeline has a awakening effect on mice under enflurane anesthesia. No dose-dependent awakening effect for lobeline is found in mice.

作者陆悦李晴晴张文文吴悠陈莹王晶晶王玉珏周帅武玉清

机构地区徐州医学院麻醉学院徐州医学院麻醉药理学教研室

出处《徐州医学院学报》 CAS 2013年第8期500-501,共2页 Acta Academiae Medicinae Xuzhou

基金国家自然科学基金（81070889,81171013）江苏省高校自然科学基金重大资助项目（10KJA320052）江苏省高校大学生实践创新训练计划项目江苏高校优势学科建设工程资助项目

关键词催醒洛贝林恩氟烷麻醉 awakening effect lobeline enflurane anesthesia

分类号 R971.2 [医药卫生—药品] R965.1 [医药卫生—药理学]

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参考文献3

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