摘要
急性胰腺炎发病急骤，病情变化迅速，可并发急性肺损伤（ALI）及急性呼吸窘迫综合征（ARDS），甚至发生多器官功能障碍综合征，病死率一直居高不下。急性胰腺炎并发ALI及ARDS的机制错综复杂，涉及炎症反应失控、细胞的损伤与凋亡、胰酶的作用、凝血与纤溶失衡等多个层面，而这些层面彼此相互关联形成复杂的网络。深入探讨急性胰腺炎并发ALI及ARDS的机制，将为临床诊治提供更多新的作用靶点。
Acute panereatitis happens rapidly and leads to patient＇s condition changing swiftly. Acute panereatitis may be complicated by acute lung injury （ALI） and acute respiratory distress syndrome （ARDS）, or even multiple organ dysfunction syndrome, and the mortality rate has been high. The meehanism of acute panereatitis with complications of ALI and ARDS is intricate. It involves the uncontrolled inflammatory response, the damage and ap- optosis of cell, the role of trypsin, the imbalance of coagulation and fibrinolysis, etc. These respects interrelate with each other,forming a complex network. Further study of mechanism of acute pancreatitis complicated with ALI and ARDS will supply more new target for clinical diagnosis and treatment.
出处
《国际外科学杂志》
2013年第8期561-565,共5页
International Journal of Surgery
基金
北京市博士后科研活动经费资助（No.201322-24）
关键词
胰腺炎
急性坏死性
急性肺损伤
呼吸窘迫综合征
成人
Pancreatitis acute necrotizing
Acute lung injury
Respiratory distress syndrome, adult
