摘要
Objective： To investigate the correlation between different Chinese medicine （CM） syndromes and variations in microcirculation in septic shock patients. Methods： seventy Septic shock patients were divided into four groups： heat damaging qi-yin group （HDQY, 23 cases）; yin exhaustion and yang collapse group （YEYC, 26 cases）; excessive heat in Fu organ group （EHFO, 10 cases）; and heat damaging nutrient-blood group （HDNB, 11 cases）. Sublingual microcirculation parameters were observed by sidestream dark-field （SDF） imaging and scored by Acute Physiology and Chronic Health Evaluation Ⅱ （APACHE Ⅱ） and the Sequential Organ Failure Assessment （SOFA）, and parameters of microcirculation perfusion variations and prognoses were analyzed. Results： Compared with those with qi-yin heat damage, perfused vessel density （PVD） in other groups decreased dramatically （P〈0.05）, and APACHE H scores increased significantly （P〈0.05）. In addition, the recovery time was prolonged substantially （P〈0.05）, and the mixed venous oxygen saturation （SVO2） decreased （P〈0.05）. Blood lactic acid increased significantly （P〈0.05）, and the mixed SVO2 decreased （P〈0.05）, in the YEYC group. Compared with the thermal injury camp blood group, sublingual microcirculation parameter variations showed no obvious difference in the YEYC and EHFO groups （P〉0.05）. There were significant positive correlations between CM syndromes and APACHE Ⅱ scoring in different groups （r=0.512, P〈0.05）. There were negative correlations between PVD and APACHE Ⅱ scoring （r=-0.378, P=0.043）, the proportion of perfused vessels （PPV） and APACHE g scoring （r=0.472, P=0.008）, as well as between the microvascular flow index （MFI） and APACHE Ⅱ scoring （r=-0.424, P=0.023） in different patients. Conclusion： Sublingual microcirculation may serve as a clinical diagnostic parameter of the patient condition, as well as being a prognostic indicator.
Objective： To investigate the correlation between different Chinese medicine （CM） syndromes and variations in microcirculation in septic shock patients. Methods： seventy Septic shock patients were divided into four groups： heat damaging qi-yin group （HDQY, 23 cases）; yin exhaustion and yang collapse group （YEYC, 26 cases）; excessive heat in Fu organ group （EHFO, 10 cases）; and heat damaging nutrient-blood group （HDNB, 11 cases）. Sublingual microcirculation parameters were observed by sidestream dark-field （SDF） imaging and scored by Acute Physiology and Chronic Health Evaluation Ⅱ （APACHE Ⅱ） and the Sequential Organ Failure Assessment （SOFA）, and parameters of microcirculation perfusion variations and prognoses were analyzed. Results： Compared with those with qi-yin heat damage, perfused vessel density （PVD） in other groups decreased dramatically （P〈0.05）, and APACHE H scores increased significantly （P〈0.05）. In addition, the recovery time was prolonged substantially （P〈0.05）, and the mixed venous oxygen saturation （SVO2） decreased （P〈0.05）. Blood lactic acid increased significantly （P〈0.05）, and the mixed SVO2 decreased （P〈0.05）, in the YEYC group. Compared with the thermal injury camp blood group, sublingual microcirculation parameter variations showed no obvious difference in the YEYC and EHFO groups （P〉0.05）. There were significant positive correlations between CM syndromes and APACHE Ⅱ scoring in different groups （r=0.512, P〈0.05）. There were negative correlations between PVD and APACHE Ⅱ scoring （r=-0.378, P=0.043）, the proportion of perfused vessels （PPV） and APACHE g scoring （r=0.472, P=0.008）, as well as between the microvascular flow index （MFI） and APACHE Ⅱ scoring （r=-0.424, P=0.023） in different patients. Conclusion： Sublingual microcirculation may serve as a clinical diagnostic parameter of the patient condition, as well as being a prognostic indicator.
基金
Supported by the Fund of Medicine Development in Beijing(No.SF-2009-Ⅱ-14)
