摘要
目的观察900 MHz手机频率辐射12 d、18 d对雄性SD大鼠肝组织形态和功能的影响。方法选育龄期SD雄鼠30只。将雄性大鼠按体重均衡的原则随机分为3组,正常组、12 d、18 d辐射组。正常组不接受辐射,辐射组分别接受900 MHz手机频率辐射连续12 d、18 d4 h/d,于辐射结束次晨处死。观察比较3组大鼠血清丙氨酸转氨酶(ALT)、门冬氨酸氨基转移酶(AST)及二者比值,雄鼠肝脏HE染色。结果与正常组比较,12 d和18 d辐射组血清ALT、AST无显著性改变;肝的HE染色结果显示:与正常组比较,12 d辐射组肝小叶结构基本完整,肝细胞核部分萎缩或消失;18 d辐射组肝小叶结构基本完整,肝细胞肿大及部分细胞质空泡样变明显。结论 900 MHz手机频率辐射雄性SD大鼠可造成大鼠肝损伤,细胞核萎缩并逐渐肿大和空泡样变,血清AST、ALT无显著性改变。
Objective To investigate the influence of frequency radiation of 900MHz cellular phone on the liver structure and function of rats at different time points. Methods Thirty adult male SD rats were randomly divided into three groups, control group, 12-day radiation group and 18-day radiation group. The rats in control group did not receive radiation, the rats in radiation groups received frequency radiation from 900MHz cellular phone for 12 days and 18 days （4h/d） ,respectively. Finally the serum levels of ALT and AST were detected and the changes of liver structure were observed by HE staining. Results As compared with those in control group, the serum levels of ALT and AST were not obviously changed in 12-day radiation group and 18-day radiation group. HE staining results showed that as compared with that in control group, hepatic lobules was clear, hepatocyte nuclear was partly atrophy or disappeared in 12-day radiation group, and hepatic lobules structure was basically complete, hepatocyte was swelling and vacuolar degeneration appeared in part of cytoplasm in 18-day radiation group. Con- clusion The frequency radiation of 900MHz cellular phone can result in hepatic injury of rats, with hepatocyte nu- clear atrophy, swelling and vacuolar degeneration, however, serum levels of ALT and AST are not obviously changed.
出处
《河北医药》
CAS
2013年第20期3048-3049,共2页
Hebei Medical Journal
基金
河北省教育厅一般项目(编号:2009146)
河北医科大学科研骨干人才培育计划(编号:2009017)
河北医科大学大学生创新性实验计划项目(编号:USIP201209A)
关键词
手机频率
雄性大鼠
肝功能
frequency of cellular phone
male rats
liver function
