摘要
目的探讨阿仑膦酸钠增加绝经后妇女骨密度,降低骨折的疗效。方法陕西省人民医院老年病门诊及住院患者,用简单随机化方法分为研究组和对照组。研究疗程为12个月,在治疗前、6个月末和12个月末对阿仑膦酸钠的疗效进行评估。结果本研究共入组60例(碳酸钙组:30例、阿仑膦酸钠组:30例),在6个月末和12个月末:髋骨的骨密度阿仑膦酸钠组较碳酸钙组明显增高,差异有统计学意义(P<0.05)。骨钙素测定阿仑膦酸钠组较碳酸钙组明显降低,差异有统计学意义(P<0.05)。尿Ⅰ型胶原氨基末端肽/肌酐(NTX/Cr)阿仑膦酸钠组较碳酸钙组明显降低(P<0.01)。再发骨折率阿仑膦酸钠组(3.33%)较碳酸钙组(16.67%)明显下降(P<0.01)。结论与碳酸钙对比,阿仑膦酸钠降低骨转换,增加绝经后骨质疏松症患者的骨密度,减少骨折发生率。
Objective To study the change of bone mineral density （BMD） in postmenopausal osteoporosis after alendronate treatment. Methods Patient selected from the Geriatric Departement of Shanxi Provincial People Hospital with simple randomized method, the research object will be divided into experimental group and control group. The whole treatment lasted for 12 months, before and during the treatment, at end of 6 and 12 months of alendr- onate did curative effect evaluation. Results Sixty cases were analyzed （calcium carbonate group 30 casesand alen- dronate sodium group 30 cases）. After treatment, at the end of 6 and 12 months： hip bone mineral density of aleudr- onate group was significantly higher than that of calcium carbonate group, and the results have significant difference （ P 〈 0. 05 ）. Osteocalcin in alendronate group reduced significantly than that in calcium carbonate group （ P 〈 0. 05 ）. Type I collagen amino terminal peptide （NTX/Cr） in alendronate group also reduced significantly than that in calci- um carbonate group （P 〈 0. 01 ）. Fracture rate of alendronate group was 3.33%, while calcium carbonate group was 16.67%. Two groups were dramatically different, P 〈 0. 001. Conclusion Compared with calcium carbonate, alendr- onate could reduce bone conversion,increase the bone mineral density, and reduce the incidence of fracture in postm- enopausal osteoporosis.
出处
《中国临床保健杂志》
CAS
2013年第5期487-489,共3页
Chinese Journal of Clinical Healthcare
基金
陕西省科技厅社发公关项目(2007K15-05)
关键词
骨质疏松
绝经后
二磷酸盐类
骨密度
碳酸钙
Osteoporosis, postmenopausal
Diphosphonates
Bone density
Calcium carbonate
