摘要
目的 :观察川芎嗪预防用药对动脉粥样硬化 (AS)家兔血清一氧化氮 (NO)、血浆内皮素 (ET)、脂质过氧化物(MDA)和超氧化物歧化酶 (SOD)的影响。方法 :采用高胆固醇饲料喂饲另加牛血清白蛋白一次注射方法 ,建立家兔AS模型 ,随机分为对照组、模型组和川芎嗪用药组 ,在实验第 8周取血清标本测定上述参数。结果 :与模型组比较 ,川芎嗪预防用药 8周 ,能提高NO和SOD活性 (P <0 .0 1) ,降低ET和MDA含量 (P <0 .0 1)。结论 :川芎嗪具有抗氧化、保护内皮功能和维持NO/ET平衡的作用。
Objective:To observe the effects of Ligustrazine on nitric oxide(NO),endothelin(ET),lipid peroxide and superoxide dismutase(SOD) in experimental atherosclerotic rabbit.Methods:An atherosclerotic rabbit model was established by feeding high cholesterol diet supplemented by bovine serum albumin injection bolus.The rabbits were randomly divided into the control,model,and Ligustrazine treated group.Blood samples were collected 8 weeks after relevent treatment.Results:after 8 weeks Ligustrazini administration,compared with model group,the NO and activity of SOD increased( P <0.01),while MDA and ET decreased( P <0.01).Conclusion:Ligustrazini possesses the effects of antioxidation,preserving endothelial fonction,and maintaining thd balance of NO/ET.
出处
《湖北民族学院学报（医学版）》
2000年第4期4-5,共2页
Journal of Hubei Minzu University(Medical Edition)
关键词
动脉粥样硬化
一氧化氮
内皮素
川芎嗪
MDA
Atherosclerosis
Nitric oxide
Endothelin
Lipid peroxide
Ligustrazini
