摘要
目的了解多重耐药菌的临床分布,为减少临床多重耐药菌的发生提供依据。方法分离济南军区总医院2006年1月至2011年12月住院患者送检的各类标本,经VITEK-32或VITEK-2 COMPACT 60(2007年11月以后)微生物鉴定系统鉴定并用纸片扩散法进行药物敏感性试验,数据采用WHO-NET 5.4软件统计分析。结果 2006年1月至2011年12月多重耐药菌医院感染呈逐年递增趋势,产超广谱β-内酰胺酶(ESBLs)细菌感染率最高,泛耐药鲍曼不动杆菌(PDR-AB)和广泛耐药铜绿假单胞菌(XDR-PA)感染率上升明显;多重耐药菌主要分布在保健科、神经外科、重症医学科、普外科、血液科等患有基础疾病并长期使用抗菌药物的老年患者、重大外科手术等危重症患者,以及免疫能力低下或免疫抑制的患者;仍以呼吸道感染最多见。结论多重耐药菌医院感染逐年增多,应加强耐药监测,建立适合我国具体情况的感染控制措施,减低医院感染率。
Objective To understand the distribution trend of multidrug-resistant strains, in order to provide the reference of decreasing the incidence of multidrug-resistant strain infection. Methods All kinds of samples from Inpatient Department in Jinan Military General Hospital from January 2006 to December 2011 were collected. The strains were identified by VITEK-32 or VITEK-2 COMPACT 60 （ after November 2007 ）, and the susceptibility testing was determined by Kirby-Bauer method. The data were analyzed statistically by WHO-NET 5.4 software. Results From January 2006 to December 2011, multidrug-resistant strain infection had increasing trend, and the infection rate of extended spectrum beta-lactamases （ESBLs）-producing strains was highest. The infection rates of pandrug-resistant Acinetobacter baumannii （PDR-AB） and extensively drug-resistant Pseudomonas aeruginosa （XDR-PA） increased obviously. Multidrug-resistant strains were mainly in Departments of Health, Neurosurgery, Intensive Care Unit, Surgery and Hematology among the eider and serious patients with long-term use of antibiotics and immunosuppressant. The main clinical manifestation was respiratory tract infection. Conclusions Muhidrug-resistant strain hospital infections have increased year by year, and the monitoring of drug resistance should be strengthened. The prevention should be established in order to reduce the rate of hospital infections.
出处
《检验医学》
CAS
2013年第9期784-788,共5页
Laboratory Medicine
关键词
多重耐药菌
临床分布
感染控制
Multidrug-resistant strain
Clinical distribution
hffection control
