摘要
目的:目前药物性肝损伤(DILI)缺乏特异性的实验室诊断标准。通过分析药物性肝损伤患者的实验室检测数据特点,以提高医生对该病的认识及诊断水平。方法:根据急性药物性肝损伤诊断及分类的国际共识标准,应用SPSS l0软件进行数据处理,回顾性分析2009年以来我院收治的139例药物性肝损伤病例的临床资料包括相关实验室检查:肝功能、血常规、血清总IgE、肝抗原谱及凝血功能。结果:药物性肝损伤患者以肝细胞型为主(46.0%),其次为混合型(29.5%),胆汁淤积型(24.5%)。97.1%预后良好,但也有少数出现肝衰竭(2.8%)。同时实验室检查发现药物性肝损伤病例的血常规、血清总IgE、肝抗原谱可有异常改变,而比较中、西药组的这些实验室检查的改变没有统计学差异。结论:药物性肝损伤发病率逐年增多,需要临床医师熟悉并掌握其临床特点,通过综合评价提高对本病的诊治水平。
Objective： Drug-induced liver injury（DILI） is lack of specific laboratory diagnostic criteria at present.In order to improve the dignostic knowledge of DILI for clinicians,the characteristic of laboratory data of DILI cases was analyzed.Methods： According to the international consensus standards for the diagnosis and classification of DILI,the incidence of disease and the experimental results of 139 patients with DILI in our hospital since 2009 were retrospectively analyzed.The analyzed experimental data include liver function,blood routine,quantity of serum IgE,liver antigen spectrum and coagulation function using SPSS 10 software.Results： The majority of DILI cases belongs to hepatocellular type（46.0%）,follow by the mixed type（29.5%） and cholestasis type（24.5%）..Most of cases（97.1%） were eusemia.Only a small number of cases（2.8%） appeared liver function failure.Meanwhile,anomalies of lab test were observed in blood routine,quantity of serum IgE and liver antigen spectrum of DILI population.Consideration of such changes there is no significant difference between patients taking traditional Chinese medicine and western medicine.Conclusion： The mobidity of DILI is increasing year by year.The clinical features and comprehensive evaluation of characteristic of laboratory tests may help us to improve the diagnosis of DILI.
出处
《中国医药导刊》
2013年第8期1356-1357,1359,共3页
Chinese Journal of Medicinal Guide
