摘要
目的:观察分析依达拉奉联合银杏达莫治疗2型糖尿病并发急性脑梗塞的临床疗效以及安全性。方法:将48例在48h内发病的糖尿病并发急性脑梗塞患者随机分成治疗组和对照组,两组均为24例患者。治疗组给予依达拉奉30mg+生理盐水100ml进行静脉滴注,每日2次,同时给予(银杏达莫30ml+生理盐水250ml)静脉滴注,每日1次,连用14d;对照组给予同等剂量,同疗程的银杏达莫,同时给予(胞二磷胆碱500mg+生理盐水)250ml静脉滴注。2组患者在进行治疗前及后14d时进行临床神经功能缺损程度评分及临床疗效评定、并通过TCD观察颅内血管平均血流速度(Vm)与阻力指数(RI)的变化和不良反应。结果:治疗组有效率(96)显著高于对照组(87)。两组患者治疗后神经功能评分均有明显改善,但治疗组明显优于对照组(P<0.05),经TCD观察比较48例患者治疗前后椎基底动脉血流速度以及改善脑部血流情况上,治疗组疗效明显优于对照组,P<0.05,P<0.001。两组均未见不良反应。结论:依达拉奉联合银杏达莫治疗2型糖尿病并发急性脑梗塞的临床效果更加明显且安全。
Objective：To observe and analysis the clinical efficacy and safety of edaravone combined with ginkgo leaf extract and dipyridamole in the treatment of type 2 diabetes complicated with acute cerebral infarction. Methods：48 cases in 48h patients of diabetes mellitus complicated with acute cerebral infarction were randomly divided into treatment group and control group, two groups of 24 patients. Treatment group were given edaravone 30mg＋100ml normal saline for intravenous drip, 2 times a day, while giving （Ginkgo leaf extract and dipyridamole 30ml＋physiological saline 250ml） intravenous infusion, 1 times daily, for 14d;control group received the same dose, the same course of ginkgo leaf extract and dipyridamole, while giving （cell two choline 500mg＋saline） 250ml intravenous drip note. 2 groups of patients with clinical neurological impairment score and the clinical curative effect evaluation, in the treatment before and after 14d TCD was used to observe the mean blood flow velocity of intracranial vascular （Vm） and resistance index （RI） changes and adverse reactions.Results：The effective rate of the treatment group （96） was significantly higher than that of the control group （87）. The nerve function score was significantly improved after treatment in two groups, but the treatment group was significantly better than the control group （P〈0.05）, the TCD were observed in 48 patients before and after treatment of vertebral basilar artery blood flow velocity and improve brain blood flow, significantly better than the control group, the curative effect of treatment group P〈0.05, P〈0.001. The two groups were no adverse reaction.Conclusion：The clinical effect of edaravone combined with ginkgo leaf extract and dipyridamole in treatment of type 2 diabetes mellitus complicated with acute cerebral infarction is more obvious and safe.
出处
《中国医药导刊》
2013年第9期1499-1500,1502,共3页
Chinese Journal of Medicinal Guide
关键词
2型糖尿病
急性脑梗塞
依达拉奉
银杏达莫
经颅多普勒(TCD)
Type 2 diabetes
Acute cerebral infarction
Edaravone
Ginkgo leaf extract and dipyridamole
Transcranial Doppler（TCD）
