摘要
目的:探讨调强适形放射治疗(IMRT)与三维适形放射治疗(3D-CRT)技术治疗原发性肝癌的临床剂量学。方法:选取入住本院的45例原发性肝癌患者,针对每例患者制定2套放射治疗计划,比较计划靶区(PTV)的平均剂量、最小剂量、最大剂量及最大剂量与处方剂量的百分比、靶区适形指数以及靶区均匀指数,分析危及器官的照射剂量。结果:统计分析显示,最小受照剂量(PTVD min)中,两者差异无统计学意义(t=0.037,P>0.05);平均受照剂量(PTVD mean)、最大受照剂量(PTVDmax)、靶区最大剂量与处方剂量的百分比(PTVDmax/%)、靶区剂量均匀度指数(HI)和适形度指数(CI)IMRT与3D-CRT差异均具有统计学意义(t=35.631,t=4.136,t=3.428,t=2.123,t=15.996;P<0.05)。危及器官的照射剂量分析中,IMRT在肾脏、胃、十二指肠和脊髓的剂量明显低于3D-CRT的照射剂量。结论:IMRT能有效地提高靶区的照射剂量,降低危及器官的损伤。
Objective： To explore the clinical dosimetry of intensity modulated radiation therapy（IMRT） and three dimensional conformal radiotherapy（3D-CRT） for hepatocellular carcinoma treatment. Methods： Firstly, making radiotherapy schemes of IMRT and 5D-CRT for each patient among 45 ones in our hospital. Secondly, comparing PTVDmean, PTVDmin, PTVDmax, PTVDmax% , CI and HI. Finally, analyzing the dosage which endangers patient＇s organs. Results： Comparation analysis results show that there is no statisiicai difference in PTVDmin （t=0.037, P 〉0.05）, but there is significant statistical difference in PTVDmean, PTVDmax, PTVDmax/%, HI and CI between IMRT and 3D-CRT （t=35.631, t=4. 136, t=3.428, t=2. 123, t= 15.996; P〈0.05）. Dosage analysis results show that IMRT remains in kidney, small intestine and spinal cord is remarkably less than the 3D-CRT. Conclusion： IMRT can effectively increase the radiation dose in target areas, reduce organ damage, and improve life quality of the patients.
出处
《中国医学装备》
2013年第9期96-98,共3页
China Medical Equipment
