摘要
目的研究质子泵抑制剂三联疗法治疗十二指肠球部溃疡的效果。方法选择80例经胃镜检查确诊Hp阳性的十二指肠球部溃疡患者,随机分为A组40例、B组40例,A组用兰索拉唑30 mg,qd×4周,克拉霉素0.5 g,bid×1周,阿莫西林1.0 g,bid×1周;B组用法莫替丁20 mg,bid×4周,克拉霉素0.5 g,bid×1周,阿莫西林1.0 g,bid×1周。疗程(4周)结束后,复查胃镜并做14C呼气试验及快速尿素酶试验,比较两组的溃疡愈合率、Hp根除率。结果 A、B组的溃疡愈合率分别为95.0%、82.5%,Hp根除率为92.5%、70.0%。A、B两组的溃疡愈合率、Hp根除率比较,差异有统计学意义(P<0.05)。结论兰索拉唑三联疗法能有效根除Hp,是治疗十二指肠球部溃疡比较理想的方法。
Objective To study the effect of triple therapy of proton pump inhibitors treating duodenal bulbar ulcer. Methods 80 patients with duodenal bulbar ulcer confirmed with Hp positive by gastroscope examination were selected and randomly divided into the group A （n=40） and the group B （n=40）.The group A were treated by lansoprazole 30 mg once daily for four weeks,clarithromycin 0.5 g twice daily for one week, and amoxicillin 1.0 g twice daily for one week;while the group B were treated by famotidine 20 mg twice daily for four weeks and the same usage of clarithromycin and amoxicillin.After completion of treatment course （four weeks）,gastroscope examination and C14 expiratory test and rapid urease test were conducted,the rate of HP eradicating and ulcer healing of the two groups were compared. Results The rate of ulcer healing in the group A and the group B was 95.0% and 82.5% respectively,and the rate of Hp eradicating was 92.5% and 70.0% respectively,and there was a statistical difference of the rate of Hp eradicating and ulcer healing in the two groups （P〈0.05）. Conclusion Lansoprazole triple therapy can effectively eradicate Hp,and it is an ideal method for treating duodenal bulbar ulcer.
出处
《中国当代医药》
2013年第28期76-77,共2页
China Modern Medicine
