摘要
目的分析血液病住院患者合并侵袭性真菌病（IFD）的流行病学情况。方法收集2007年1月至2012年12月天津市第一中心医院住院血液病合并IFD患者419例，对其诊断层次、感染部位以及相关因素对发病率的影响进行分析。结果（1）419例IFD中拟诊233例（55．61％），临床诊断140例（33．41％），确诊46例（10．98％）。（2）46例确诊患者中43例为粒细胞缺乏者，36例为曲霉菌感染。（3）IFD患者中，肺IFD所占比例最大，为85．20％（357／419）。（4）IFD患者中恶性血液病化疗导致粒细胞缺乏者所占比例最大，而血液恶性肿瘤未化疗者IFD发病率有上升趋势。（5）41～60岁是IFD发生率最高的年龄段。（6）419例患者诊断IFD时均正在应用抗生素，多为同时使用2种（205例，48．93％）或3种（179例，42．72％）抗生素者。（7）1、7、12月份为IFD发病高峰，6月份为IFD发病小高峰。结论粒细胞缺乏是血液病合并IFD的主要原因，对于指导血液系统疾病合并IFD的早期诊断、经验性治疗有一定的参考价值。
Objective To explore the epidemiological profiles of invasive fungal disease （IFD）in hospitalized patients with hematological diseases during 2007 -2012. Methods A total of 419 IFD patients with hematological diseases from January 2007 to December 2012 were reviewed. All of them were analyzed with regards to diagnostic levels, infection sites and various related factors. Results （ 1 ） A total of 233 cases （55.61% ） were preliminarily identified as IFD, 140 cases （ 33.41% ） had a clinical diagnosis and 46 cases （10. 98% ） were confirmed cases of IFD. （2）Among 46 confirmed cases of IFD, there were agranulocytosis （n = 43 ） and aspergillosis infection （n = 36 ）. （3）Respiratory tract was the most frequent infection site in all IFD patients （ 85.20% ） . （ 4 ） And chemotherapy-induced agranulocytosis was a major reason for IFD patients with hematological diseases. The number of IFD patients without chemotherapy had a rising trend. （5） The age group of IFD was during 41 -60 years old. （6）All of them stayed on antibiotic therapy at the diagnosis of IFD. The numbers of antibiotics were two（205 cases,48.93% ）and three（ 179 cases,42. 72% ）. （7） The peak incidence of IFD was recorded in January, July and December. And June was another lower peak. Conclusions Agranulocytosis is the main reason for IFD patients with hematological disease. The data is important and valuable for the early diagnosis and therapy of IFD patients with hematological disease.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2013年第36期2876-2879,共4页
National Medical Journal of China
关键词
血液病
真菌病
流行病学
Hematological diseases
Mycoses
Epidemiology
