摘要
目的:比较分析99 Tcm-MIBI显像平面与断层扫描对鼻咽癌放化疗疗效预测价值。方法:2008-03-2011-12随机选取甘肃省肿瘤医院接受放化疗的初治鼻咽癌患者60例,放疗前后行99 Tcm-MIBI显像。显像方法为静脉推注99 Tcm-MIBI 740MBq后于1h进行单光子发射计算机断层成像/计算机断层扫描技术(single photonemission computerized tomography and computerized tomography,SPECT-CT)平面+断层扫描,图像采集完成后计算肿瘤摄取比值T/N。结果:60例患者中平面显像阳性率为61.7%(37/60),断层显像阳性率为83.3%(50/60),断层显像阳性率明显高于平面显像,差异有统计学意义,χ2=7.06,P=0.008。显像阳性患者1h平面和断层显像T/N值分别为3.21±1.2和3.6±1.8,差异有统计学意义,t=2.75,P=0.003;线性相关分析显示,两者呈正相关,r=0.834,P=0.001。各疗效组平面显像及断层显像比较差异均有统计学意义,其中平面显像,F=42.322,P=0.004;断层显像,F=42.265,P=0.006。放疗后平面和断层显像的T/N值分别为1.21±0.34和1.26±0.34,差异有统计学意义,t=13.3,P=0.003。放疗后平面和断层T/N值与放疗前平面和断层T/N值比较差异具有统计学意义,其中平面显像,F=96.491,P=0.008;断层显像,F=153.997,P=0.009。结论:99 Tcm-MIBI显像SPECT-CT断层扫描在显像容积比值及显像阳性率方面优于平面扫描,通过检测鼻咽癌患者99 Tcm-MIBI是否显像及计算T/N值对预测放疗疗效有一定的价值。
OBJECTIVE：To compare the imaging 99Tcm-MIBI with planar and tomography scanning for predicting the effect in radiochemtherapy foi the nasopharyngeal carcinoma（NPC）. METHODS： Sixty patients with untreated NPC from March of 2008 to December of 2011 in Gansu Tumor Hospital were included in the study, single photonemission computerized tomography and computerized tomography（SPECT-CT） was performed at 1 h with planar and tomography after intravenous injection of 740 MBq 99 Tcm MIBI before and after radiotherapy, tumor uptake ratio T/N was calculated after image acquisition. RESULTS： The sensitivity of imaging for diagnosing of NPC was 61.7 % （37/60） in planar imaging and 83.3 % （50/60） in tomography imaging,and there was a significant difference （χ2 = 7.06, P = 0. 008）. T/N values of SPECT were 3.21± 1.2 and 3.6 ± 1.8 in planar and tomography imaging especially （t= 2.75, P= 0. 003） ; Linear correla- tion analysis was positively correlated（r= 0. 834,P= 0. 001）. The differences were statistically significant when compared SPECT imaging with efficacy,the planar （F=42. 322 ,P=0. 004） and .the tomography （F=42. 265 ,P〈0. 006）. The T/N values of SPECT were 1.21±0.34 and 1.26±0.34 in planar and tomography imaging especially after radiotherapy （t= 13.3 ,P=0. 003） ; The T/N value of planar and tomography imaging were lower after radiotherapy than before radiother- apy, there were significant differences with planar （F= 96. 491, P = 0. 008） and tomography （F= 153. 997, P = 0. 009）.CONCLUSIONS： 99 Tcm-MIBI imaging with SPECT-CT tomography scanning is superior to planar imaging in imaging vol- ume ratio and the positive rate. We can predict the effect in radiochemtherapy for NPC by detecting whether 99 Tcm_MIBI scintigraphy and calculating the T/N ratio.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2013年第18期1425-1428,共4页
Chinese Journal of Cancer Prevention and Treatment
基金
甘肃省科技厅创新团队资助项目(098TTCA009)
甘肃省科技厅技术研究与开发专项计划项目(2GS064-A43-020-16)
