摘要
目的:通过对中山小榄地区646例新生儿脐血红细胞葡萄糖-6-磷酸脱氢酶(G6PD)缺乏症筛查结果的分析,了解小榄地区G6PD缺乏症的特征。方法:选择孕妇及其新生儿各646例,采用速率法对孕妇及其新生儿脐血进行G6PD缺乏症筛查。结果:①在小榄地区新生儿脐血G6PD缺乏筛查中,总缺乏率为9.1%,其中男性缺乏率为11.8%(36/306),高于女性缺乏率(P<0.05)。②男性G6PD活性为(2.40±2.51)U/gHb,低于女性G6PD活性(10.21±2.33)U/gHb(P<0.05)。③在G6PD缺乏的孕妇所生子女中,男性新生儿脐血缺乏率为45.5%,女性新生儿脐血缺乏率38.9%,男性新生儿脐血缺乏率与女性相比无统计学差异(P>0.05)。④男性新生儿高胆红素血症发生率为19.4%,女性新生儿高胆红素血症发生率13.0%,差异无统计学意义(P>0.05)。结论:①小榄地区是新生儿脐血G6PD缺乏症高发区,以男性多见而严重;②母亲G6PD缺乏者,其新生儿G6PD缺乏率高,属于不完全显性遗传;③G6PD缺乏是新生儿发生高胆红素血症的病因之一。
Objective： To study the characteristics of glucose -6 -phosphate dehydrogenase （G6PD） deficiency in Zhongshan Xiaolan region by analyzing the experimental results of newborn umbilical cord blood G6PD activity. Methods： 646 cases of pregnant women and their newborns were chosen, pregnant women＇s serum and their newborn umbilical cord blood G6PD were detected by velocity method and analyzed. Results： ①In newborn umbilical cord blood G6PD screening study, total G6PD activity defective rate of Zhongshan Xiaolan re- gion was 9. 1%, the lacks rate of male was 11.8% higher than that of female （P 〈0. 05）. ②The G6PD activity of male （2. 40 U/glib ± 2. 51 U/glib） lower than that of female （ 10. 21 U/glib ±2. 33 U/glib） （P 〈0. 05） . ③In pregnant women lack of G6PD, the lacks rate of male of their infants was 45.5% and that of female was 38.9% in umbilical cord blood, the difference was no significant （P 〉0. 05） . ④The rate of neonatal hyperbilirnbinemia in male was 19.4% and that in female was 13.0% , the differences between the groups were no significant （ P 〉 0. 05 ） . Conclusion： ①Neonatal G6PD deficiency is higher incidence in Zhongshan Xiaolan region, male is more common and severe; ②In pregnant women lack of G6PD, the lacks rate of their infants is higher and show incomplete dominance heredity; ③G6PD deficiency is one o f the causes of neonatal hyperbilirnbinemia.
出处
《中国妇幼保健》
CAS
北大核心
2013年第28期4671-4674,共4页
Maternal and Child Health Care of China
关键词
中山小榄
新生儿
脐带血
G6PD缺乏症
Zhongshan Xiaolan
Newborn
Umbilical cord blood
G6PD deficiency
