摘要
以最近开发的双膦-铑配合物[Rh((R,R)-QuinoxP*)(cod)]SbF6作为催化剂,利用不对称催化氢化方法合成了一系列D-(R)-酪氨酸衍生物,在S/C=10000条件下获得了99%ee的对映选择性.并将所得的氢化产物成功应用于具有重要生理活性的化合物(R)-2-羟基-3-(3,4-二羟基苯基)丙酸钠的合成.相比于已报道的方法,该工艺路线产率更高而且不需要柱层析分离,因而非常具有工业化应用前景.
Using a recently developed catalyst[Rh（（R,R）-QuinoxP＊）（cod）]SbF6, several derivatives of D-（R）-tyrosine were prepared with up to 99% ee via catalytic asymmetric hydrogenation. The substrates chosen for asymmetric hydrogenation were readily synthesized from the inexpensive and accessible compound 4-hydroxybenzaldehyde. The product resulting from the asymmetric hydrogenation was practically applied to the preparation of an important bioactive compound sodium （R）-3-（3,4-dihydroxyphenyl）-2-hydroxypropanoate through a feasible process.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2013年第9期1932-1938,共7页
Chinese Journal of Organic Chemistry
基金
上海市经济与信息化委员会基金(No.12CH-02)资助项目~~
