摘要
目的探讨益气健脾中药联合肠内营养剂对慢性阻塞性肺病合并呼吸衰竭患者营养的影响。方法该研究收集青岛市海慈医疗集团ICU2010年10月-2012年1月收治的40例慢性阻塞性肺病合并呼吸衰竭危重症患者,采用随机对照试验方法,按照统一标准将入选病例分为对照组和试验组各20例。对照组采用常规肠内营养剂,试验组在常规肠内营养剂基础上加用益气健脾中药（四君子汤）,分别在治疗当天（第1天）、治疗第5天、治疗第10天记录患者总蛋白、白蛋白、前白蛋白、血红蛋白等营养学指标和主要安全性指标。结果治疗第5天,两组总蛋白和白蛋白均有增长,但组内、组间比较差异均无统计学意义（P〉0.05）;两组前白蛋白均有增长,组内比较差异无统计学意义（P〉0.05）,但组间比较差异有统计学意义（P〈0.05）,试验组增长更明显。治疗第10天,对照组总蛋白和白蛋白均有增长,但组内比较差异均无统计学意义（P〉0.05）;试验组总蛋白和白蛋白均有增长,组内比较差异有统计学意义（P〈0.05）,组间比较差异有统计学意义（P〈0.05）,试验组增长更明显。两组前白蛋白均有增长,对照组组内比较仅第10天和第1天比较差异有统计学意义（P〈0.05）,试验组组内比较差异均有统计学意义（P〈0.05）,组间比较差异有统计学意义（P〈0.05）,试验组增长更明显。血红蛋白在对照组和试验组变化不大,差异均无统计学意义（P〉0.05）。结论该研究认为,慢性阻塞性肺病合并呼吸衰竭危重症患者存在营养不良,通过单纯的肠内营养不能明显改善患者营养不良的状况,而在常规肠内营养基础之上,添加四君子汤通过益气健脾可以明显改善患者营养不良状况,证实了益气健脾法在改善慢性阻塞性肺病合并呼吸衰竭患者的营养状况方面有一定的应用前景。
【Objective】 To explore the method of Replenishing Qi to invigorate spleen combined with enteral nutrition therapy in COPD complicated with respiratory failure patients.【Methods】 40 cases of COPD complicated with respiratory failure critically patients data in Qingdao Hiser Hospital from October 2010 to January in 2012 were retrospectively analyzed.According to the unified criteria of patients selection,all the subjects were divided into two groups,the control group only received enteral nutrition,the experiment group received enteral nutrition combined with Replenish Qi to invigorate spleen.Nutritional markers such as Total protein（TP）,Albumin（ALB）,Preabumin（PA）,Hemoglobin（HB） were detected in the two groups on the first day before the nourishment therapy,and the 5th and 10th day after treatment.【Results】 On the 5th day,the value of TP and ALB increased in the two groups,but there were no statistically significance（P 0.05） between the two groups and within group.The value of PA increased in the two groups,there were no statistically significance（P 0.05） within group.There were statistically significance（P 0.05） between the two groups,the value in the experiment group were higher.On the 10th day,the value of TP and ALB increased in the control group,but there were no statistically significance（P 0.05） within group.The value of TP and ALB increased in the experiment group,there were statistically significance（P 0.05） within group,while statistically significance（P 0.05） between the two groups,the value in the experiment group were higher.The value of PA increased in the two groups,there were statistically significance（P 0.05） between the 1st day and the 10th day in control group,and statistically significance（P 0.05） in the experiment group,the value in the experiment group were higher.The value of Hb increased a little in the two groups,there were no statistically significance（P 0.05） between the two groups and within group.【Conclusions】 We consider that the patients with COPD complicated with respiratory failure were in the state of malnutrition and it cannot be improved only by the method of enteral nutritional.But it can be improved significantly using Replenishing Qi to invigorate spleen therapy combined with enteral nutrition.It is confirmed that there has application value by the method of Replenishing Qi to invigorate spleen combined with enteral nutrition therapy in COPD complicated with respiratory failure patients.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2013年第23期89-93,共5页
China Journal of Modern Medicine
基金
青岛市卫生资助项目(No:2009-WSZD030)
关键词
益气健脾
四君子汤
慢性阻塞性肺病
呼吸衰竭
机械通气
营养不良
Replenishing Qi to invigorate spleen
decoction of four mild drugs
COPD
respiratory fail ure
mechanical ventilation
malnutrition
