摘要
目的:观察艾灸循经筋对膝骨性关节炎的镇痛疗效以及对破骨细胞分化因子(RANKL)及破骨细胞分化抑制因子(OPG)调控机制的表达影响。方法:采用随机原则将膝骨关节炎患者分为经穴组、阿是穴组以及循经筋规律性阿是穴组,共90例患者,连续治疗4周。分别于治疗前后采用疼痛VAS评分比较,抽取膝关节滑液分离细胞,检测RANKL及OPG表达变化,观察比较各疗法的镇痛疗效和对RANKL及OPG调控机制。结果:三组均有明显的镇痛效果,经穴组与阿是穴组治疗后RANKL及OPG显著降低,循经筋阿是穴组具有更强的抑制RANKL及OPG表达的作用,统计学有显著性差异。结论:艾灸对膝骨关节炎止痛效果良好,在抑制RANKL及OPG介导的炎症反应方面,经穴灸法与阿是穴灸法具有明显的抑制作用,且循经筋阿是穴灸法疗效更佳。
Objective： After moxibustion treatment, RANKL and OPQ expressions were investigated in knee osteoarthritis （KOA） to study the analgesic and anti-inflammatory mechanism of treatments. Methods： 90 cases of KOA patients were randomly divided into traditional acupuncture moxibustion group, A-shi acupuncture point moxibustion group and moxibustion group with Meridian-Muscle-Lesion Rules, and were treated individually for 4 weeks once a day. After 4 weeks treatment, Visual Analogue Scale （VAS） was measured, and RANKL and OPG expressions were investigated in synovial cell from KOA. Resuhs： VAS showed significant difference in all groups. 1RANKL and OPG expressions were decreased in traditional acupuncture and A-shi acupuncture point moxibustion group after the treatments, and moxibustion group with Meridian-Muscle-Lesion Rules showed stronger depression effects than other two groups （P〈0.05）. Conclusion： Moxibustion treatment showed an excellent analgesic effect in KOA, and moxibustion group with Meridian-Muscle-Lesion Rules showed significant depression effects of RANKL and OPG expression, and moxihustion group with Meridian-Muscle-Lesion Rules showed stronger clinical effect than traditional acupuncture and A-shi acupuncture point inoxibustion group.
出处
《辽宁中医药大学学报》
CAS
2013年第10期5-7,共3页
Journal of Liaoning University of Traditional Chinese Medicine
基金
沈阳市科技局基金项目(F12-277-1-51)
辽宁百千万人才工程培养经费资助项目
