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男性抗NMDA受体脑炎1例并文献复习 被引量：11

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摘要 抗N-甲基-D-天冬氨酸受体（N．methyl．D-asparatereceptor，NMDAR）脑炎是一种自身免疫性脑炎，自2007年被Dal—mau等一在一组表现为记忆力下降、精神症状、意识障碍及中心性通气障碍的患者体内发现抗NMDAR抗体以来倍受国内外学者关注。截止到目前为止，国内经临床确诊的抗NMDAR脑炎患者并不多。英国一项多中心前瞻陛脑炎病因的研究显示∞0，抗NMDA受体脑炎约占全部脑炎的4％，发病率仅次于急性播散性脑脊髓膜炎，而且该病主要发生在伴有卵巢畸胎瘤的年轻女性患者之中，男性及儿童较为少见。现将我院收治的1例抗NMDAR脑炎的男性患者病例报告如下，并结合文献进行进一步的分析讨论。
作者 赵洋洋 韩艳秋
机构地区 吉林大学第二医院神经内科
出处 《中风与神经疾病杂志》 CAS CSCD 北大核心 2013年第9期836-838,共3页 Journal of Apoplexy and Nervous Diseases
关键词 NMDA受体 男性患者 文献复习 脑炎 N-甲基-D-天冬氨酸受体 NMDAR 女性患者 自身免疫性
分类号 R512.3 [医药卫生—内科学]
  • 相关文献

参考文献4

二级参考文献27

  • 1Vitaliani R, Mason W, Anees B, et al. Paraneoplastic encephalitis, psychiatric symptoms, and hypoventilation in ovarian teratoma. Ann Neurol, 2005, 58: 594-604.
  • 2Dalmau J, Tuzun E, Wu HY, et al. Paraneoplastic anti-N- methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol, 2007, 61: 25-36.
  • 3Dalmau J, Lancaster E, Martinez-Hernandez E, et al. Clinical experience and laboratory investigations in patients with anti- NMDAR encephalitis. Lancet Neurol, 2011, 10:63-74.
  • 4Dalmau J, Gleichman AJ, Hughes EG, et ah Anti-NMDA- receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol,2008, 7: 1091-1098.
  • 5Gable MS, Gavali S, Radner A, et al. Anti-NMDA receptor encephalitis: report of ten cases and comparison with viral encephalitis. Eur J Clin Microbiol Infect Dis, 2009, 28: 1421- 1429.
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共引文献43

同被引文献185

  • 1刘娟丽,王莉,杨春晓.抗NMDA受体脑炎新进展[J].中风与神经疾病杂志,2012,29(2):190-192. 被引量：18
  • 2许景芝,黄宇明.肺癌致副肿瘤性边缘叶脑炎1例[J].罕少疾病杂志,2006,13(1):41-42. 被引量：4
  • 3Vitaliani R,Mason W,Anees B,et al.Paraneoplastic encephalitis,psychiatric symptoms,and hypoventilation in ovarian teratoma[J].Ann Neurol,2005,58:594-604.
  • 4Dalmau J,Tfizfin E,Wu HY,et al.Paraneoplastic anti-N-Methyl-Daspartate receptor encephalitis associated with ovarian teratoma[J].Ann Neurol,2007,61(1):25-36.
  • 5Granerod J,Ambrose HE,Davies NW,et al.Causes of encephalitis and differences in their clinical presentations in England:a multicenter,population-based prospective study[J].Lancet Infect Dis,2010,10(12):835-844.
  • 6Dalmau J,Lancaster E,Martinez-Hernandez E,et al.Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis[J].Lancet Neurol,2011,10(1):63-74.
  • 7Lizuka T,Sakai F.Anti-NMDA receptor encephalitis in Japan:longterm outcome without tumor removal[J].Neurology,2008,70(7):504-511.
  • 8Dalmau J,Gleichman AJ.Anti-NMDA-receptor encephalitis:case series and analysis of the effects of antibodies[J].Lancet Neurol,2008,7(12):1091-1098.
  • 9Ishiura H,Matsuda S.Response of anti-NMDA receptor encephalitis without tumor to immunotherapy including rituximab[J].Neurology,2008,71(23):1921-1923.
  • 10Poloni C,Korff CM,Ricotti V,et al.Severe childhood encephalopathy with dyskinesia and prolonged cognitive disturbances:evidence for anti-N-methyl-D-aspartate receptor encephalitis[J].Dev Med Child Neurol,2010,52:78-82.

引证文献11

二级引证文献34

中风与神经疾病杂志
2013年 第9期

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