摘要
目的了解自发性腹膜炎的病原菌分布及耐药情况,为临床合理使用抗菌药物提供依据。方法对本院2008年3月-2012年8月诊断为自发性腹膜炎的住院患者为研究对象,分离到的病原菌采用法国生物梅里埃公司VITEK2Compact微生物鉴定仪鉴定菌种,K-B法检测细菌的药敏结果。结果分离到菌株206株,病原菌以革兰阴性菌为主,少数革兰阳性菌。革兰阴性杆菌对亚胺培南,头孢哌酮/舒巴坦,阿米卡星的抗菌活性最好,对氨苄西林、环丙沙星高度耐药。革兰阳性球菌对万古霉素,阿米卡星的抗菌活性最好,对青霉素高度耐药。结论腹水中感染的病原菌多重耐药菌较多,需对自发性腹膜炎的腹水进行病原菌及耐药性监测,以便临床根据细菌培养及药敏结果合理选用抗菌药物。
Objective To understand the distribution and drug resistance, of pathogenic bacteria in patients with spontaneous bacterial peritonitis, providing the basis for clinical rational use of antimicrobial drugs. Methods The hospitalized patients with spontaneous bacterial peritonitis form March 2008 to August 2012 were involved in this study. The pathogenic bacteria iso- lates from these patients were identified by VITEK2 Compact microbe instrument of France bioMerieux company. K - B method was used to analyze the drug sensitivity test results of the pathogenic bacteria. Results A total of 206 pathogenic strains were i- solated, mainly gram - negative bacilli and less gram - positive bacilli. Gram - negative bacilli had better antibacterial activity to imipenem, cefoperazone/sulbactam and amikacin, but high drug resistance to ampicillin and ciprofloxacin. While gram - pos- itive bacilli had better antibacterial activity to vancomycin and amikacin, but high resistance to penicillin. Conclusion Patho- genic bacteria in aseites infection are found multi - drug resistance, so monitoring on pathogen and drug resistance should be carried out in patients with spontaneous bacterial peritonitis for rational use of antibacterial agents according to clinical bacteria culture and srug sensitivity test results.
出处
《中国卫生检验杂志》
北大核心
2013年第11期2532-2533,共2页
Chinese Journal of Health Laboratory Technology
关键词
自发性腹膜炎
病原菌
耐药性
Spontaneous peritonitis
Pathogenic bacteria
Drug resistance
