采用动态血糖监测评价二甲双胍联合胰岛素治疗对血糖的影响
被引量:1
摘要
胰岛β细胞分泌功能异常和胰岛素抵抗是糖尿病发生、发展的主要机制,而高血糖是加重胰岛β细胞功能衰竭和胰岛素抵抗的主要因素。长期暴露于高血糖环境中,糖尿病患者的大血管和微血管并发症会随之增加。及早启动胰岛素治疗可促进胰岛β细胞功能的恢复,延缓糖尿病并发症的来临。然而目前无论使用何种胰岛素治疗,都存在血糖波动过大及低血糖的风险。
出处
《中国药物与临床》
CAS
2013年第10期1339-1340,共2页
Chinese Remedies & Clinics
参考文献5
-
1纪立农.“β-细胞休息”概念及其在糖尿病防治中的应用[J].国外医学(内分泌学分册),2003,23(3):180-181. 被引量:174
-
2李延兵,翁建平.保护β细胞功能以改善2型糖尿病的自然病程[J].国外医学(内分泌学分册),2005,25(3):181-183. 被引量:76
-
3Boyne MS,Silver DM,Kaplan J,et al. Tiiming of changes in in- terstitial and venous blood glucose measured with a continuous subcutaneous glucose sensorl.Diebetes, 2003,52: 2790-2794.
-
4周健,喻明,贾伟平,李青,李鸣,马晓静,陆蔚,项坤三.应用动态血糖监测系统评估2型糖尿病患者日内及日间血糖波动幅度[J].中华内分泌代谢杂志,2006,22(3):286-288. 被引量:177
-
5王淑芳,曲晓红,赵颖.罗格列酮和二甲双胍治疗新发2型糖尿病的疗效比较[J].中国糖尿病杂志,2006,14(6):415-416. 被引量:7
二级参考文献11
-
1喻明,周健,项坤三,陆惠娟,马晓静,陆蔚.动态监测糖耐量正常者血糖水平的漂移变化[J].中华医学杂志,2004,84(21):1788-1790. 被引量:50
-
2Service FJ, Molnar GD, Rosevear JW, et al. Mean amplitude of glycemic excursions, a measure of diabetic instability. Diabetes, 1970,19:644-655.
-
3Molnar GD, Taylor WF, Ho MM. Day-to-day variation of continuously monitored glycaemia: a further measure of diabetic instability. Diabetologia, 1972,8:342-348.
-
4Selam JL. How to measure glycemic instability? Diabetes Metab, 2000,26:148-151.
-
5Muggeo M, Verlato G, Bonora E, et al. Long-term instability of fasting plasma glucose, a novel predictor of cardiovascular mortality in elderly patients with non-insulin-dependent diabetes mellitus: the Verona Diabetes Study. Circulation, 1997,96:1750-1754.
-
6Risso A, Mercuri F, Quagliaro L, et al. Intermittent high glucose enhances apoptosis in human umbilical vein endothelial cells in culture.Am J Physiol Endocrinol Metab, 2001,281 :E924-E930.
-
7Yu JG,Javorschi S,Hevener AL,et al.The effect of thiazolidinediones on plasma adiponectin levels in normal,obese and type 2 diabetic subjects.Diabetes,2002,51:2968-2974.
-
8Boden G,Cheung P,Mozzoli M,et al.Effect of thiazolidinediones on glucose and fatty acid metabolism in patients with type 2 diabetes.Metabolism,2003,52:753-759.
-
9Stumoll M,Gerich J.Clinical features of insulin resistance and beta cell dysfunction and the relationship to type 2 diabetes.Clin Lab Met,2001,21:31-51.
-
10Lebovitz HE,Dole JF,Patwardhan R,et al.Rosiglitazone monotherapy is effective in patients with type 2 diabetes.J Clin Endocrinol Metab,2000,86:280-288.
共引文献428
-
1李琳琳,祝盈,刘晓利,杨珊珊,周柳男,吴月凤.护理干预对预防老年糖尿病低血糖的效果分析[J].实用临床护理学电子杂志,2020(32):59-59.
-
2童颖剑,刘嬿.动态血糖监测联合胰岛素泵对老年糖尿病患者血糖控制的疗效观察[J].医学信息(医学与计算机应用),2016,29(32):196-196. 被引量:4
-
3黄瑞华,钱金华,曹秀娟,曹玉梅.早期胰岛素强化治疗对初发2型糖尿病胰岛β细胞功能的影响[J].医学信息(医学与计算机应用),2014,0(21):608-608. 被引量:1
-
4何琼芳,李作敏,沈海定.胰岛素泵强化治疗糖尿病患儿临床护理[J].实用医技杂志,2008,15(7):904-905.
-
5靳秀琴,马跃龙.胰岛素短期强化治疗成人糖调节受损18例临床观察[J].中国医药指南,2008,6(15):111-112. 被引量:2
-
6郭法平.胰岛素的4种不同应用方法对糖尿病治疗作用和血糖各项指标的影响[J].中医药临床杂志,2009,21(1):16-17. 被引量:4
-
7曹英华,赵铁梅.诺和锐30治疗初诊2型糖尿病临床观察[J].中国实用医药,2007,2(5):65-66.
-
8冯玉婕.护理干预对心理性胰岛素抵抗的影响[J].中国老年保健医学,2006,4(4):62-63.
-
9叶志东.新诊2型糖尿病胰岛素强化治疗的临床评价[J].吉林医药学院学报,2006,27(4):203-205. 被引量:1
-
10王春.Ⅱ型糖尿病患者心理性胰岛素抵抗护理进展[J].护理实践与研究,2008,5(3):70-71. 被引量:2
同被引文献17
-
1伍华,陈敏,邵丽香,等.西格列汀联合二甲双胍治疗初发2型糖尿病的临床观察[J].中国医药,2013,8(z1):18-19.
-
2Kelly AS, Bergenstal RM, Gonzalez-Campoy JM, et al. Effects of exenatide vs. metformin on endothelial function in obese patients with pre-diabetes: a randomized trial[J]. Cardiovasc Diabetol, 2012, 11: 64.
-
3Nadeau DA. Physiologic and weight-focused treatment strategies for managing type 2 diabetes mellitus: the metformin, glucagon-like peptide-1 receptor agonist, and insulin (MGI) approach[J]. Postgrad Med, 2013, 125(3): 112-126.
-
4Kato Y, Koide N, Komatsu T, et al. Metformin attenuates production of nitric oxide in response to lipopolysaccharide by inhibiting MyD88-independent pathway[J]. Honn Metab Res, 2010, 42(9): 632-636.
-
5Cheng AY, Fantus IG. Oral antihyperglycemic therapy for type 2 diabetes mellitus[J]. CMAJ, 2005, 172(2): 213-226.
-
6Dunn CJ, Peters DH. Metformin. A review of its pharmacological properties and therapeutic use in non-insulin-dependent diabetes mellitus[J]. Drugs, 1995, 49(5): 721-749.
-
7A1-Khalili L, Forsgren M, Kannisto K, et al. Enhanced insulin- stimulated glycogen synthesis in response to insulin, metformin or.rosiglitazone is associated with increased mRNA expression of GLUT4 and peroxisomal proliferator activator receptor gamma co- activator l[J]. Diabetologia, 2005, 48(6): 1173-1179.
-
8Thakkar B, Aronis KN, Vamvini MT, et al. Metformin and sulfonylureas in relation to cancer risk in type lI diabetes patients: a meta-analysis using primary data of published studies [J]. Metabolism, 2013, 62(7): 922-934.
-
9张丹丹,刘芳.二甲双胍的多重抗癌机制[J].中华医学杂志,2013,93(12):956-958. 被引量:7
-
10安慧杰,洪天配,王产,魏蕊,刘烨,杨进,张琳.二甲双胍对波动性高糖诱导的内皮细胞功能障碍的逆转作用及其机制[J].中华糖尿病杂志,2013,5(4):231-234. 被引量:7
-
1黄燕飞.脂毒性与2型糖尿病及其并发症的关系[J].肾脏病与透析肾移植杂志,2002,11(1):58-62. 被引量:9
-
2张菲菲,张文健,娄晋宁,门秀丽.内质网应激对2型糖尿病胰岛β细胞凋亡的影响[J].医学研究杂志,2010,39(6):6-9. 被引量:2
-
3徐波,张瑛.2型糖尿病一级亲属中胰岛β细胞功能评价[J].辽宁医学杂志,2011,25(3):136-138. 被引量:1
-
4黄红艳.45例糖尿病足的临床分析[J].医学文选,2006,25(4):642-644.
-
5李建华.糖尿病患者临床病程与血清C肽水平的关系初探[J].放射免疫学杂志,2003,16(4):220-220.
-
6李昌臣.2型糖尿病胰岛素治疗的利弊与评价[J].辽宁实用糖尿病杂志,2002,10(2):10-12. 被引量:13
-
7徐燕,董凌玲.胰岛素泵治疗老年2型糖尿病的健康教育[J].实用医技杂志,2005,12(12A):3538-3539.
-
8董志春,徐华永,楼丽颖,裘静英,任于晗,肖招英.2型糖尿病患者胰岛素强化治疗前后C反应蛋白变化与胰岛素抵抗相关性观察[J].浙江医学,2009(6):815-816.
-
9刘敏,蔡德鸿.血管紧张素Ⅱ对胰岛β细胞功能及胰岛素敏感性的影响[J].广东医学,2008,29(1):152-153. 被引量:2
-
10周广朋,陈树.2型糖尿病胰岛β细胞功能衰竭与糖尿病性心力衰竭[J].实用医院临床杂志,2014,11(4):284-287. 被引量:8