摘要
目的分析血药浓度监测对丙戊酸钠预防神经外科术后癫痫发作的意义,为临床提供参考。方法回顾性分析2012年我院神经外科248例脑肿瘤患者围手术期应用丙戊酸钠的血药浓度结果,并根据术后患者的临床资料,癫痫发作情况,评估丙戊酸钠围手术期预防癫痫的疗效。结果血药浓度在正常治疗范围内有160例,占64.5%,高于正常治疗浓度范围有18例,占7.3%,低于正常治疗浓度范围70例,占28.2%。结论丙戊酸钠的血药浓度易受多种因素的影响,应根据患者的基本情况,通过血药浓度监测进行个体化给药,使丙戊酸钠维持有效治疗浓度对围手术期预防癫痫有重要意义。
To discuss the role of blood concentration monitoring of sodidum valproate in preventing postoperative seizure. Methods 248 cases of sodium valproate blood concentration of brain tumor patients were retrospective analyzed in 2012, and the prophylaxis effect of epilepsy was assessed through the analysis of postoperative epilepspy in hospital. Results Normal treatment concentration was found in 160 cases（64.5%）, 18 cases（7.3%） were higher than normal treatment concentration, and 70 cases（28.2%） below the normal treatment concentration. Conclusion The blood concentration of sodium valproate was influenced by many factors. According to patients＂ basic situation and blood concentration moni- toting, the individualized medication should be made so as to Keep an effective therapeutic concentration of sodium valproate to prevent seizares during the perioperative period.
出处
《中国药物警戒》
2013年第9期520-522,共3页
Chinese Journal of Pharmacovigilance
关键词
丙戊酸钠
围手术期
预防
血药浓度
个体化治疗
sodium valproate
perioperative period
prophylaxis
blood concentration
individualized medication
