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Wnt／β-catenin信号转导通路与脑胶质瘤

Wnt/β-catenin signaling pathway and glioma
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摘要 Wnt／β-catenin信号转导通路是一种在进化中高度保守的信号通路，它参与了胚胎生长、发育、能量代谢和干细胞维持等多种生物学过程的调控。Wnt／β-catenin通路的异常激活与肿瘤的发生密切相关。探讨Wnt／β-catenin信号转导通路与脑胶质瘤细胞增殖、侵袭、凋亡和肿瘤新生血管形成的关系将为脑胶质瘤的治疗提供新的靶点与干预措施。 Wnt/β-catenin signaling pathway is highly conserved in evolution, which involves in the regulation of a variety of biological processes such as embryonic growth, development, energy metabolism and stem cells maintenance. Aberrant activation of Wnt/β-catenin signaling pathway has a closely relationship with tumorigenesis. Investigating the role of Wnt/β-catenin signaling in glioma cell proliferation, invasion, apoptosis and tumor angiogenesis will provide novel therapeutic targets and intervening measures for glioma treatment.
作者 陈梦娜 刘婷 郭庚
机构地区 山西医科大学第一临床医学院 山西医科大学第一医院神经外科
出处 《国际肿瘤学杂志》 CAS 2013年第9期668-670,共3页 Journal of International Oncology
基金 国家自然科学基金（81201991） 山西省基础研究计划青年科技研究基金（2012021035-5）
关键词 神经胶质瘤 细胞增殖 肿瘤侵润 细胞凋亡 WNT Β-CATENIN信号通路 Glioma Cell proliferation Neoplasm invasiveness Apoptosis Wnt/β-catenin signalingpathway
分类号 R739.4 [医药卫生—肿瘤]
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参考文献27

  • 1Nager M,Bhardwaj D,Cant! C,et al. ^-Catenin signalling in glio-blastoma multiforme and glioma-initiating cells. Chemother Res Pract,2012, 2012:192362.
  • 2Park DM, Rich JN. Biology of glioma cancer stem cells. Mol Cells,2009,28(1) :7-12.
  • 3Verhaak RG,Hoadley KA, Purdom E, et al. Integrated genomicanalysis identifies clinically relevant subtypes of glioblastoma charac-terized by abnormalities in PDGFRA, IDH1,EGFR, and NF1. Canc-er Cell, 2010, 17(1):98-110.
  • 4Saxeddy GR,Challa S, Panigrahi M,et al. Wnt/beta-catenin/Tcfsignaling pathway activation in malignant progression of rat gliomasinduced by transplacental N-ethyl-N-nitrosourea exposure. NeurochemRes, 2009, 34(7):1278-1288.
  • 5Guo G,Kuai D, Cai S, et al. Knockdown of FRAT1 expression byRNA interference inhibits human glioblastoma cell growth, migrationand invasion. PLoS One, 2013, 8(4) : e61206.
  • 6Sareddy GR,Panigrahi M,Challa S,et al. Activation of Wnt/beta-catenin/Tcf signaling pathway in human astrocytomas. NeurochemInt, 2009, 55(5) :307-317.
  • 7Liu C,Tu Y, Sun X, et al. Wnt/beta-Catenin pathway in human gli-oma: expression pattern and clinical/prognostic correlations. Clin ExpMed, 2011,11(2) :105-112.
  • 8Liu X, Wang L, Zhao S, et al. p-Catenin overexpression in malig-nant glioma and its role in proliferation and apoptosis in glioblastmacells. Med Oncol, 2011, 28(2) :608-614.
  • 9Guo G, Mao X, Wang P,et al. The expression profile of FRAT1 inhuman gliomas. Brain Res, 2010,1320: 152-158.
  • 10Pe 6ina-Slaus N,Marti 6 TN, Kokotovi 6 T, et al. AXIN-1 proteinexpression and localization in glioblastoma. Coll Antropol, 2011,35Suppl 1:101-106.
国际肿瘤学杂志
2013年 第9期

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