摘要
肾纤维化是多种病因诱导细胞因子过度表达,引起肾脏间质细胞增殖失调及细胞间质代谢失调、过量细胞外基质积聚、肾脏组织结构破坏及功能丧失的病理过程,最终导致肾衰竭。细胞因子是肾纤维化进展的关键因素。在各种病因刺激下,细胞因子过度表达并通过各种信号通路控制细胞核基因转录,导致肾纤维化。目前肾纤维化信号通路主要涉及转化生长因子β/Smad信号转导通路、丝裂原激活蛋白激酶级联信号通路、腺苷信号通路。该文着重阐述各信号通路转导途径及其相互关系,总结肾纤维化发生、发展的主要分子机制。
Renal fibrosis is characterized by over-expression of cytoklnes, matrix cell prohlerahon disor-ders and interstitial cells metabolic disorders, ultimately leading to renal destruction and dysfunction. It＇s a common consequence of chronic kidney diseases caused by multiple pathogenic factors. Renal fibrosis process is involved by a variety of molecules signaling pathways. Cytokine is the key factor of renal fibrosis and con- trols gene transcription through various signaling pathways ,which can cause renal fibrosis. Here is to make a review of the pathogenesis of renal fibrosis and research progress from a molecular perspective, such as trans-forming growth facter-β/Smad pathway, mitogen-activated protein kinases cascade signaling pathway and adenosine pathway,we also give a brief cross-talk of them to provide a comprehensive sUmmary of the main molecular mechanisms in renal fibrosis.
出处
《医学综述》
2013年第18期3275-3278,共4页
Medical Recapitulate
基金
湖南省科技计划项目(2010FJ4088)
