摘要
目的探讨罹患影响血流动力学的动脉导管未闭(hsPDA)的极低出生体质量儿围手术期管理方案。方法2006年1月至2011年12月,22例出生体质量小于1500g的早产儿行PDA结扎术,其中男12例,女10例;胎龄中位数分别为29周(24+5~32+6周);出生体质量(1103±228)g。出生时Apgar评分1min为(6.1±2.2)分,5min(8.6±1.2)分。结果患儿PDA直径(3.79±1.01)mm(2.0~5.9mm),(2.69±0.84)mm/kg(1.23~4.23mm/kg);左心房与主动脉根部直径比(LA:AO)1.69±0.41。手术时体质量中位数1500g,平均(1512±539)g;日龄中位数24天。麻醉意外导致死亡1例;其余21例完成手术的患儿中,住院(67.09±36.10)天,术后呼吸机治疗2~44天,15例(68.2%)术后7天内撤机。围手术期主要并发症包括肺出血(18.2%)、坏死性小肠结肠炎(13.6%)、败血症(22.7%)、支气管肺发育不良(63.7%)、脑损伤(18.1%)、早产儿视网膜病变(31.8%)、肺炎(86.4%)、代谢性酸中毒(45.5%)。结论对于极低出生体质量儿hsPDA,早期确诊、积极干预很关键,如不能行内科治疗或内科治疗无效时,特别是大PDA(〉3.5mm或2.5mm/kg)、合并其他左向右分流的心内畸形时,应在出现各种严重并发症之前争取尽早手术治疗,手术结扎安全、有效。
Objective The aim of this study is to retrospectively analyze perioperative managements of very-low-birth- weight(VLBW) preterms with hemodynamic significant patent ductus arteriosus (hsPDA). Methods Between January 2006 and December 2011, totally 22 VLBW preterms with hsPDA underwent surgical ductal ligation. There were 12 boys and 10 girls. The median gestatianal age was 29 weeks(24 +5 -32 +6 weeks). The birth weight was ( 1103±228) g(640 - 1440 g). The Apgar score was 6.1 ± 2.2 at 1 minute, 8.6 ± 1.2 at 5minutes. The average ductal size was ( 3.79 ± 1.01 ) mm (2.0 - 5.9 ram) , (2.69 ± 0.84) mm/kg( 1.23 - 4.23 mm/kg) , left atrial diameter to aortic root ratio( LA : AO) was 1.69 ±0. 41. The median weight at surgery was 1500 g(640 -2100 g), average (1512± 539 ) g. The median age at surgery was 24 days ( 11 - 167 days). Results 1 case death because of anesthetic accident. The average hospitalization days were (67.1 ± 36.1 ) days. The days of ventilation treatment after surgery were 2 -44 days, 15 cases (68.2%) weaned from mechanical ventilation within seven days after surgeries. The complications includes puhnonary hemorrhage ( 18. 2% ), necrotizing enterocolitis ( 13.6% ) ,septicemia(22.7% ), broncho-pulmonary dysplasia (63.7%), brain injury( 18.1% ), retinopathy of prematurity (31.8%) ,pneumonia (86.4%) and metabolic acidosis(45.5% ). Conclusion For VLBW preterms with hsPDA, early diagnosis and early interfere are key points. Surgical PDA ligation is a promising option to avoid severe complications when medi- cal treatments are ineffective.
出处
《中华胸心血管外科杂志》
CSCD
北大核心
2013年第9期513-516,共4页
Chinese Journal of Thoracic and Cardiovascular Surgery
基金
广东省科技厅社会发展项目基金(2009800700062,2009803081263)
广东省医学科研基金(B2012014)
关键词
动脉导管未闭
婴儿
极低出生体重
围手术期医护
Ductus arteriosus, patent Infant, very low birth weight Perioperative care