期刊文献+

极低出生体质量儿hsPDA围手术期治疗策略 被引量:6

Perioperative managements of VLBW preterms with hsPDA
原文传递
导出
摘要 目的探讨罹患影响血流动力学的动脉导管未闭(hsPDA)的极低出生体质量儿围手术期管理方案。方法2006年1月至2011年12月,22例出生体质量小于1500g的早产儿行PDA结扎术,其中男12例,女10例;胎龄中位数分别为29周(24+5~32+6周);出生体质量(1103±228)g。出生时Apgar评分1min为(6.1±2.2)分,5min(8.6±1.2)分。结果患儿PDA直径(3.79±1.01)mm(2.0~5.9mm),(2.69±0.84)mm/kg(1.23~4.23mm/kg);左心房与主动脉根部直径比(LA:AO)1.69±0.41。手术时体质量中位数1500g,平均(1512±539)g;日龄中位数24天。麻醉意外导致死亡1例;其余21例完成手术的患儿中,住院(67.09±36.10)天,术后呼吸机治疗2~44天,15例(68.2%)术后7天内撤机。围手术期主要并发症包括肺出血(18.2%)、坏死性小肠结肠炎(13.6%)、败血症(22.7%)、支气管肺发育不良(63.7%)、脑损伤(18.1%)、早产儿视网膜病变(31.8%)、肺炎(86.4%)、代谢性酸中毒(45.5%)。结论对于极低出生体质量儿hsPDA,早期确诊、积极干预很关键,如不能行内科治疗或内科治疗无效时,特别是大PDA(〉3.5mm或2.5mm/kg)、合并其他左向右分流的心内畸形时,应在出现各种严重并发症之前争取尽早手术治疗,手术结扎安全、有效。 Objective The aim of this study is to retrospectively analyze perioperative managements of very-low-birth- weight(VLBW) preterms with hemodynamic significant patent ductus arteriosus (hsPDA). Methods Between January 2006 and December 2011, totally 22 VLBW preterms with hsPDA underwent surgical ductal ligation. There were 12 boys and 10 girls. The median gestatianal age was 29 weeks(24 +5 -32 +6 weeks). The birth weight was ( 1103±228) g(640 - 1440 g). The Apgar score was 6.1 ± 2.2 at 1 minute, 8.6 ± 1.2 at 5minutes. The average ductal size was ( 3.79 ± 1.01 ) mm (2.0 - 5.9 ram) , (2.69 ± 0.84) mm/kg( 1.23 - 4.23 mm/kg) , left atrial diameter to aortic root ratio( LA : AO) was 1.69 ±0. 41. The median weight at surgery was 1500 g(640 -2100 g), average (1512± 539 ) g. The median age at surgery was 24 days ( 11 - 167 days). Results 1 case death because of anesthetic accident. The average hospitalization days were (67.1 ± 36.1 ) days. The days of ventilation treatment after surgery were 2 -44 days, 15 cases (68.2%) weaned from mechanical ventilation within seven days after surgeries. The complications includes puhnonary hemorrhage ( 18. 2% ), necrotizing enterocolitis ( 13.6% ) ,septicemia(22.7% ), broncho-pulmonary dysplasia (63.7%), brain injury( 18.1% ), retinopathy of prematurity (31.8%) ,pneumonia (86.4%) and metabolic acidosis(45.5% ). Conclusion For VLBW preterms with hsPDA, early diagnosis and early interfere are key points. Surgical PDA ligation is a promising option to avoid severe complications when medi- cal treatments are ineffective.
出处 《中华胸心血管外科杂志》 CSCD 北大核心 2013年第9期513-516,共4页 Chinese Journal of Thoracic and Cardiovascular Surgery
基金 广东省科技厅社会发展项目基金(2009800700062,2009803081263) 广东省医学科研基金(B2012014)
关键词 动脉导管未闭 婴儿 极低出生体重 围手术期医护 Ductus arteriosus, patent Infant, very low birth weight Perioperative care
  • 相关文献

参考文献16

  • 1王晨,王丹华.动脉导管未闭的药物治疗进展[J].新生儿科杂志,2005,20(2):91-94. 被引量:9
  • 2黄柏枝,陈就好,麦润婵,王德胜.布洛芬治疗早产儿动脉导管未闭效果及影响因素[J].实用儿科临床杂志,2007,22(13):1015-1016. 被引量:13
  • 3Evans N. Diagnosis of patent ductus arteriosus in the preterm new- born. Arch Dis Child,1993, 68( 1 Spec No) :58-61.
  • 4Su BH, Lin HC, Chiu HY, et al. Comparis on of ibuprofen and in- dometaein for early-targeted treatment of patent ductus arteriosus in extremely premature infants: a randomised controlled triM. Arch Dis Child Fetal Neonatal Ed,2008,93 :F94-F99.
  • 5Rheinlaender C, Helfenstein D, Walch E, et al. Total serum biliru- bin levels during cyclooxygenase inhibitor treatment for patent ductus arteriosus in preterm infants. Acta Paediatr, 2009, 98:36-42.
  • 6]Giniger RP, Buffat C, Millet V, et al. Renal effects of ibuprofen for the treatment of patent ductus arteriosus in premature infants. J Ma- tern Fetal Neonatal Med, 2007, 20:275-283.
  • 7Cherif A, Jabnoun S, Khr ouf N. Oral ibuprofen in early curative closure of patent ductus arteriosus in very premature infants. Am J Perinatol, 2007, 24:339-345.
  • 8朴锦善,刁玉霞,苗树馨.口服美林治疗早产儿动脉导管未闭23例[J].中国新生儿科杂志,2006,21(3):164-165. 被引量:4
  • 9曹云,陈超,邵肖梅,张旭东,杨群,钱甜.口服布洛芬治疗早产儿动脉导管未闭的疗效[J].实用儿科临床杂志,2006,21(1):38-40. 被引量:23
  • 10Hermes-DeSantis ER, C|yman RI. Patent ductus arteriosus: patho- physiology and management. J Perinatol, 2006, 26(Suppll ) :S14-S18.

二级参考文献62

共引文献38

同被引文献51

  • 1王晨,王丹华.动脉导管未闭的药物治疗进展[J].新生儿科杂志,2005,20(2):91-94. 被引量:9
  • 2庄建,张镜芳,陈欣欣,陈寄梅,岑坚正.全腔静脉肺动脉连接术的疗效与术式评价[J].中华胸心血管外科杂志,2007,23(3):159-161. 被引量:5
  • 3黄柏枝,陈就好,麦润婵,王德胜.布洛芬治疗早产儿动脉导管未闭效果及影响因素[J].实用儿科临床杂志,2007,22(13):1015-1016. 被引量:13
  • 4Fujimoto M, Tanahira C, Nishi MA. In non-obese pa- tients,duration of action of rocuronium is directly corre- lated with body mass index[J]. Can J Anaesth, 2013,60 (6) :552-556.
  • 5Meyhoff CS,Lund J ,Jenstrup MT, et al. Should dosing ofrocuronium in obese patients be based on ideal or correc- ted body weight[J]. Anesth Analg, 2009,109 (3) : 787- 792.
  • 6Patanwala AE, Stahle SA, Sakles JC, et al. Comparison of succinylcholine and rocuronium for first-attempt intuba- tion success in the emergency department[J]. Aead Emerg Med,2011,18(1) : 11-14.
  • 7Tang L, Li S, Huang S, et al. Desaturation following rapid sequence induction using succinylcholine vs. rocuronium in overweight patients [J]. Acta Anaesthesiol Scand, 2011,55(2) :203-208.
  • 8Jeong JS, Suh JK, Cho ES, et al. Antioxidant effect of muscle relaxants (vecuronium, rocuronium) on the rabbit abdominal aortic endothelial damage induced by reactive Oxygen species[J]. Korean J Anesthesiol, 2013,65 (6) : 552-558.
  • 9Hermes-Desantis ER, Clyman RI. Patent ductus arteriosus: pathoph- ysiology and management. J Perinatal, 2006, 26(SuppU): S14-S18.
  • 10Refai M, Brunell A, Xiu me F, et al. Short-ferm perioperative freatment with ambrorol reduces pulmonary complications and hospital costs after pulmonary lobectomy: a randomized trial. Eur J Cardiothorac Surg, 2009, 35(3): 469-473.

引证文献6

二级引证文献20

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部