摘要
目的 检测2型糖尿病患者血脂水平、凝血功能及血小板参数的变化，为防治糖尿病并发症提供依据。方法 海军总医院内分泌科2012年3－12月收治的2型糖尿病住院患者246例，男113例，女133例，年龄60.2±15.3岁，病程5～22年。根据有无糖尿病并发症分为无并发症组（n=106）及有并发症组（n=140）。以同期健康体检者120 例作为对照组。测定各组患者血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL -C）、活化部分凝血活酶时间（APTT）、凝血酶原时间（PT）、纤维蛋白原（FIB）、血小板计数（PLT）、血小板体积分布宽度（PDW）、平均血小板体积（MPV）、大血小板比率（P-LCR）等指标并进行组间比较。结果 2型糖尿病有并发症组TG、TC、LDL-C、MPV、PDW、P-LCR、FIB水平明显高于无并发症组及对照组（P〈0.05），PLT、APTT、PT明显低于无并发症组及对照组（P〈0.05），HDL-C水平3组间比较差异无统计学意义。结论 2型糖尿病患者血液处于高黏度、高凝状态，易发生血管并发症。及时进行血脂水平、凝血功能及血小板参数监测对于预防和控制糖尿病并发症具有重要意义。
Objective To determined the serum lipid profile, coagulation function and platelet parameters in patients with type 2 diabetes mellitus （T2DM）, and provide a basis for the prevention of diabetes related complications. Methods Two-hundred and forty-six T2DM patients （113 males and 133 females, aged 60.2±15.3 years, disease course 5-22 years） hospitalized in the Navy General Hospital of PLA from March to December, 2012, were involved in the present study. The patients were divided into complication group （n=140） and no complication group （n=106） according to whether there were diabetes related complications, and 120 healthy individuals were recruited as control group. The levels of serum total cholesterol （TC）, triglyceride （TG）, high-density lipoprotein cholesterol （HDL -C）, low-density lipoprotein cholesterol （LDL -C）, activated partial thromboplastin time （APTT）, prothrombin time （PT）, fibrinogen （FIB）, platelet count （PLT）, and platelet size distribution width （PDW）, mean platelet volume （MPV）, and platelet large cell ratio （P-LCR） were determined and compared among the 3 groups. Results The levels of TG, TC, LDL-C, MPV, PDW, P-LCR and FIB were significantly higher in complication group than those in no complication group and control group （P〈0.05）, and PLT, APTT and PT were significantly lower than those in no complication group and control group （P〈0.05）. No significant difference of HDL-C levels was found among the 3 groups. Conclusions The blood of patients with T2DM was in hyperviscous and/or hypercoagulable states, and it is prone to induce vascular complications. Monitoring serum lipid profile, coagulation function and platelet parameters should be beneficial for the prevention and treatment of diabetes complications.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2013年第10期851-854,共4页
Medical Journal of Chinese People's Liberation Army
关键词
糖尿病
2型
血脂异常
凝血功能
血小板功能试验
diabetes mellitus, type 2
dyslipidemias
coagulation function
platelet function tests
